BDBM50481218 CHEMBL390983::DX-619

SMILES COc1c(ccc2c1n(cc(C(O)=O)c2=O)[C@@H]1C[C@@H]1F)N1CC[C@H](C1)C1(N)CC1

InChI Key InChIKey=ZLICIITZJTYKAQ-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50481218   

TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50481218(DX-619 | CHEMBL390983)
Affinity DataIC50: 2.08E+3nMAssay Description:Inhibition of Staphylococcus aureus wild type DNA gyraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetDNA gyrase subunit A(Staphylococcus aureus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50481218(DX-619 | CHEMBL390983)
Affinity DataIC50: 1.94E+4nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase Ser84Leu mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Maharishi Markandeshwar (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM50481218(DX-619 | CHEMBL390983)
Affinity DataKi:  6.79E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed