BDBM2898 (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1,2,3,4-tetrahydroquinazolin-2-one::CHEMBL283619::DPC961

SMILES FC(F)(F)[C@]1(NC(=O)Nc2ccc(Cl)cc12)C#CC1CC1

InChI Key InChIKey=JJWJSIAJLBEMEN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 2898   

TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Dupont Pharmaceuticals

LigandPNGBDBM2898(CHEMBL283619 | (4S)-6-chloro-4-(2-cyclopropylethyn...)
Affinity DataIC50: 32nMpH: 8.2 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2004
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Instituto De Tecnologia Em F£Rmacos

Curated by ChEMBL
LigandPNGBDBM2898(CHEMBL283619 | (4S)-6-chloro-4-(2-cyclopropylethyn...)
Affinity DataIC50: 32nMAssay Description:Inhibition of HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2017
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM2898(CHEMBL283619 | (4S)-6-chloro-4-(2-cyclopropylethyn...)
Affinity DataIC50: 31nMAssay Description:The compound was evaluated for the inhibition of HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM2898(CHEMBL283619 | (4S)-6-chloro-4-(2-cyclopropylethyn...)
Affinity DataIC50: 31nMAssay Description:Tested for inhibitory concentration against HIV-1 non-nucleoside reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM2898(CHEMBL283619 | (4S)-6-chloro-4-(2-cyclopropylethyn...)
Affinity DataIC50: 31nMAssay Description:Compound was evaluated for its ability to inhibit the NNRTI HIV-1 enzyme by 50% using enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed