BDBM50438918 CHEMBL2094689::DNDI1417416::US9073941, 606

SMILES COc1ccc(cc1OC)-c1nn(C)c2nc(=O)n(C)c(=O)c2n1

InChI Key InChIKey=MWQDYWIWJRWUBC-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50438918   

TargetDNA-(apurinic or apyrimidinic site) endonuclease(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50438918(DNDI1417416 | CHEMBL2094689 | US9073941, 606)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of APE-1 (unknown origin) using double-stranded AP-site containing DNA as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50438918(DNDI1417416 | CHEMBL2094689 | US9073941, 606)
Affinity DataEC50:  870nMAssay Description:Inhibition of TDP2 (unknown origin) using 4-nitrophenyl phenylphosphonate as substrate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetDihydrolipoyl dehydrogenase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Academia Sinica

US Patent
LigandPNGBDBM50438918(DNDI1417416 | CHEMBL2094689 | US9073941, 606)
Affinity DataIC50: 960nMpH: 7.0Assay Description:The assay was performed in a manner similar to that described in Bryk et al., Biochemistry (2010) 49:1616-1627 and modified for an online robotics sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2016
Entry Details
Go to US Patent

TargetDihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Academia Sinica

US Patent
LigandPNGBDBM50438918(DNDI1417416 | CHEMBL2094689 | US9073941, 606)
Affinity DataIC50: 1.44E+3nMpH: 7.0Assay Description:Mtb PDH (Lpd+DlaT+AceE) is provided by Dr. Bryk Ruslana. The assay was performed in a manner similar to that described in Bryk et al., Biochemistry (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2016
Entry Details
Go to US Patent