BDBM50084875 8-(2,4-dichlorophenyl)-N-(1,3-dimethoxypropan-2-yl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine::CHEMBL44698::DMP-696::DMP696::[8-(2,4-dichloro-phenyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-yl]-(2-methoxy-1-methoxymethyl-ethyl)-amine

SMILES COCC(COC)Nc1nc(C)nc2c(c(C)nn12)-c1ccc(Cl)cc1Cl

InChI Key InChIKey=MDWRPTOUDPFXKK-UHFFFAOYSA-N

Data  7 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50084875   

TargetCorticotropin-releasing factor receptor 1(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084875(DMP696 | [8-(2,4-dichloro-phenyl)-2,7-dimethyl-pyr...)
Affinity DataIC50: 82nMAssay Description:Inhibition of corticotropin releasing factor receptor mediated increase in adenylate cyclase activity was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084875(DMP696 | [8-(2,4-dichloro-phenyl)-2,7-dimethyl-pyr...)
Affinity DataIC50: 40nMAssay Description:Displacement of [125I]CRF from human recombinant CRF1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50084875(DMP696 | [8-(2,4-dichloro-phenyl)-2,7-dimethyl-pyr...)
Affinity DataIC50: 1.20nMAssay Description:Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084875(DMP696 | [8-(2,4-dichloro-phenyl)-2,7-dimethyl-pyr...)
Affinity DataIC50: 39.8nMAssay Description:Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084875(DMP696 | [8-(2,4-dichloro-phenyl)-2,7-dimethyl-pyr...)
Affinity DataIC50: 39.8nMAssay Description:Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed in CHO cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50084875(DMP696 | [8-(2,4-dichloro-phenyl)-2,7-dimethyl-pyr...)
Affinity DataIC50: 1.20nMAssay Description:Displacement of [125I]Tyr-ovine-CRF from CRF1 receptor in rat frontal cortex homogenate after 2 hrs by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084875(DMP696 | [8-(2,4-dichloro-phenyl)-2,7-dimethyl-pyr...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [125I]-tyrosine-ovine-CRF from human Corticotropin releasing factor receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084875(DMP696 | [8-(2,4-dichloro-phenyl)-2,7-dimethyl-pyr...)
Affinity DataKi:  1.70nMAssay Description:Compound was tested for the binding affinity to human corticotropin releasing factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084875(DMP696 | [8-(2,4-dichloro-phenyl)-2,7-dimethyl-pyr...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to human CRF1 receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084875(DMP696 | [8-(2,4-dichloro-phenyl)-2,7-dimethyl-pyr...)
Affinity DataKi:  1.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084875(DMP696 | [8-(2,4-dichloro-phenyl)-2,7-dimethyl-pyr...)
Affinity DataKi:  1.80nMAssay Description:Compound was tested for the binding affinity to human corticotropin releasing factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084875(DMP696 | [8-(2,4-dichloro-phenyl)-2,7-dimethyl-pyr...)
Affinity DataKi:  2nMAssay Description:Antagonist activity at human CRF-1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084875(DMP696 | [8-(2,4-dichloro-phenyl)-2,7-dimethyl-pyr...)
Affinity DataKi:  2.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMed