BDBM85209 DL-THA

SMILES [C@H]([C@@H](C(=O)O)O)(C(=O)O)N

InChI Key InChIKey=YYLQUHNPNCGKJQ-UHFFFAOYSA-N

Data  3 KI  10 IC50

PDB links: 7 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 85209   

TargetExcitatory amino acid transporter 3(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM85209(DL-THA)
Affinity DataIC50: 9.55E+3nMAssay Description:Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM85209(DL-THA)
Affinity DataIC50: 3.89E+3nMAssay Description:Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM85209(DL-THA)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 3(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM85209(DL-THA)
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 4(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM85209(DL-THA)
Affinity DataIC50: 2.82E+3nMAssay Description:Inhibition of rat EAAT4 expressed in tsA201 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 4(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM85209(DL-THA)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of rat EAAT4 expressed in tsA201 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM85209(DL-THA)
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM85209(DL-THA)
Affinity DataIC50: 9.55E+3nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM85209(DL-THA)
Affinity DataIC50: 9.60E+4nMAssay Description:Inhibition of human EAAT1 transfected in African green monkey COS-1 cells assessed as reduction in [14C]glutamate uptake incubated for 12 mins by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetExcitatory amino acid transporter 2(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM85209(DL-THA)
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibition of human EAAT2 transfected in African green monkey COS-1 cells assessed as reduction in [14C]glutamate uptake incubated for 12 mins by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetGlutamate receptor 3(Rat)
Suntory Institute For Bioorganic Research

Curated by PDSP Ki Database
LigandPNGBDBM85209(DL-THA)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
Suntory Institute For Bioorganic Research

Curated by PDSP Ki Database
LigandPNGBDBM85209(DL-THA)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Suntory Institute For Bioorganic Research

Curated by PDSP Ki Database
LigandPNGBDBM85209(DL-THA)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed