BDBM14806 5,6-Diphenyl-furo[2,3-d]pyrimidin-4 -ylamine::5,6-diphenylfuro[2,3-d]pyrimidin-4-amine::DFP-4A::furanopyrimidine compound 8

SMILES Nc1ncnc2oc(c(-c3ccccc3)c12)-c1ccccc1

InChI Key InChIKey=APAOWMPUWGJZFS-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 14806   

TargetSerine/threonine-protein kinase Chk1(Human)
Vernalis (R&D)

LigandPNGBDBM14806(DFP-4A | 5,6-diphenylfuro[2,3-d]pyrimidin-4-amine ...)
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
TargetProtein Nef/Tyrosine-protein kinase HCK(Human)
University of Pittsburgh

LigandPNGBDBM14806(DFP-4A | 5,6-diphenylfuro[2,3-d]pyrimidin-4-amine ...)
Affinity DataIC50: 3.00E+4nMT: 2°CAssay Description:In vitro kinase activity of Nef-Hck complex and Hck alone using Z'-lyte kinase assay system and Tyr2 peptide substrate from Invitrogen.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase HCK(Human)
University of Pittsburgh

LigandPNGBDBM14806(DFP-4A | 5,6-diphenylfuro[2,3-d]pyrimidin-4-amine ...)
Affinity DataIC50: 3.00E+4nMT: 2°CAssay Description:In vitro kinase activity of Nef-Hck complex and Hck alone using Z'-lyte kinase assay system and Tyr2 peptide substrate from Invitrogen.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM14806(DFP-4A | 5,6-diphenylfuro[2,3-d]pyrimidin-4-amine ...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of ACK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed