BDBM227588 DCA

SMILES C(C(=O)O)(Cl)Cl

InChI Key InChIKey=JXTHNDFMNIQAHM-UHFFFAOYSA-N

Data  10 IC50  1 EC50

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 227588   

Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Human)
University of Texas Southwestern Medical Center

LigandPNGBDBM227588(DCA)
Affinity DataIC50: 1.83E+5nMpH: 7.5 T: 2°CAssay Description:To determine the IC50 for PDK inhibitors, a mixture containing 0.05-0.2 μM PDK, 6μM E1, with or without 0.5 μM of the PDC core E2/E3BP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial(Human)
University of Texas Southwestern Medical Center

LigandPNGBDBM227588(DCA)
Affinity DataIC50: 8.00E+4nMpH: 7.5 T: 2°CAssay Description:To determine the IC50 for PDK inhibitors, a mixture containing 0.05-0.2 μM PDK, 6μM E1, with or without 0.5 μM of the PDC core E2/E3BP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2017
Entry Details Article
PubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1,/2,/3,/4, mitochondrial(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM227588(DCA)
Affinity DataIC50: 2.00E+6nMAssay Description:In vitro inhibitory activity against pyruvate dehydrogenase kinase was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Human)
University of Texas Southwestern Medical Center

LigandPNGBDBM227588(DCA)
Affinity DataIC50: 5.04E+5nMAssay Description:Inhibition of PDK2 (unknown origin) using full length His6-tagged PDHA1 as substrate after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM227588(DCA)
Affinity DataIC50: 5.56E+6nMAssay Description:Inhibition of PDK3 (unknown origin) using full length His6-tagged PDHA1 as substrate after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2019
Entry Details Article
PubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial(Human)
University of Texas Southwestern Medical Center

LigandPNGBDBM227588(DCA)
Affinity DataIC50: 7.27E+5nMAssay Description:Inhibition of PDK4 (unknown origin) using full length His6-tagged PDHA1 as substrate after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2019
Entry Details Article
PubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM227588(DCA)
Affinity DataIC50: 1.03E+6nMAssay Description:Inhibition of full length His6-tagged PDK1 (unknown origin) expressed in Escherichia coli using full length His6-tagged PDHA1 as substrate after 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM227588(DCA)
Affinity DataIC50: 5.10E+6nMAssay Description:Inhibition of recombinant human GST-tagged PDK1 expressed in baculovirus infected Sf9 cells using PDHA1 as substrate measured after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Human)
University of Texas Southwestern Medical Center

LigandPNGBDBM227588(DCA)
Affinity DataIC50: 9.00E+6nMAssay Description:Inhibition of recombinant human GST-tagged PDK2 expressed in baculovirus infected Sf9 cells using PDHA1 as substrate measured after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM227588(DCA)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PDK1 (unknown origin) incubated for 30 mins followed by substrate addition measured after 60 mins in presence of ATP by ADP-Glo lumines...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM227588(DCA)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of PDK1 (unknown origin) incubated for 30 mins in presence of ATP by kinase glo luminescent kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)