BDBM50099333 2-(3,5-Dimethyl-phenoxy)-4-[5-(4-fluoro-phenyl)-3-piperidin-4-yl-3H-imidazol-4-yl]-pyrimidine::CHEMBL417255::D3RKN_55

SMILES Cc1cc(C)cc(Oc2nccc(n2)-c2c(ncn2C2CCNCC2)-c2ccc(F)cc2)c1

InChI Key InChIKey=UVLWMBRFRAMDOW-UHFFFAOYSA-N

Data  5 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50099333   

TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50099333(2-(3,5-Dimethyl-phenoxy)-4-[5-(4-fluoro-phenyl)-3-...)
Affinity DataIC50: 41nMAssay Description:Inhibitory concentration against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50099333(2-(3,5-Dimethyl-phenoxy)-4-[5-(4-fluoro-phenyl)-3-...)
Affinity DataIC50: 41nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetBromodomain testis-specific protein(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50099333(2-(3,5-Dimethyl-phenoxy)-4-[5-(4-fluoro-phenyl)-3-...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of human BRDT bromodomain 1 (unknown origin) expressed in Escherichia coli Bl21(DE3) by fluorescence anisotropyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetBromodomain testis-specific protein(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50099333(2-(3,5-Dimethyl-phenoxy)-4-[5-(4-fluoro-phenyl)-3-...)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of human BRDT bromodomain 2 (unknown origin) expressed in Escherichia coli Bl21(DE3) by fluorescence anisotropyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50099333(2-(3,5-Dimethyl-phenoxy)-4-[5-(4-fluoro-phenyl)-3-...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of BRD4 bromodomain 1 (unknown origin) expressed in Escherichia coli Bl21(DE3) by fluorescence anisotropyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50099333(2-(3,5-Dimethyl-phenoxy)-4-[5-(4-fluoro-phenyl)-3-...)
Affinity DataKd:  1.00E+4nMAssay Description:D3R2021More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2023
Entry Details
D3R

TargetTyrosine-protein kinase JAK2(Human)
D3R/Abbott

LigandPNGBDBM50099333(2-(3,5-Dimethyl-phenoxy)-4-[5-(4-fluoro-phenyl)-3-...)
Affinity DataKd:  1.00E+4nMAssay Description:D3R2022More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2023
Entry Details
D3R

TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50099333(2-(3,5-Dimethyl-phenoxy)-4-[5-(4-fluoro-phenyl)-3-...)
Affinity DataKd:  41nMAssay Description:Binding affinity to wild-type human full length p38-alpha (M1 to S360 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50099333(2-(3,5-Dimethyl-phenoxy)-4-[5-(4-fluoro-phenyl)-3-...)
Affinity DataKd:  0.470nMAssay Description:Binding affinity to p38 alpha (unknown origin) assessed as dissociation constant by DiscoverX kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed