BDBM50349213 CHEMBL1808264::D3RKN_42

SMILES CC(C)c1nc(c(s1)-c1ccnc(Nc2ccc(nc2)N2CCOCC2)n1)-c1ccc(F)c(NS(=O)(=O)c2c(F)cccc2F)c1

InChI Key InChIKey=KJUCPVIVNLPLEE-UHFFFAOYSA-N

Data  7 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50349213   

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50349213(CHEMBL1808264 | D3RKN_42)
Affinity DataIC50: 10nMAssay Description:Inhibition of ErbB4More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50349213(CHEMBL1808264 | D3RKN_42)
Affinity DataIC50: 10nMAssay Description:Inhibition of BtkMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50349213(CHEMBL1808264 | D3RKN_42)
Affinity DataIC50: 10nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetActivin receptor type-2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50349213(CHEMBL1808264 | D3RKN_42)
Affinity DataIC50: 10nMAssay Description:Inhibition of ACTR-2BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50349213(CHEMBL1808264 | D3RKN_42)
Affinity DataIC50: 10nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50349213(CHEMBL1808264 | D3RKN_42)
Affinity DataIC50: 10nMAssay Description:Inhibition of LynMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNuclear receptor coactivator 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50349213(CHEMBL1808264 | D3RKN_42)
Affinity DataIC50: 10nMAssay Description:Inhibition of Src1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50349213(CHEMBL1808264 | D3RKN_42)
Affinity DataKd:  1.70E+3nMAssay Description:D3R2021More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2023
Entry Details
D3R

TargetTyrosine-protein kinase JAK2(Human)
D3R/Abbott

LigandPNGBDBM50349213(CHEMBL1808264 | D3RKN_42)
Affinity DataKd:  7.10E+3nMAssay Description:D3R2022More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2023
Entry Details
D3R

LigandPNGBDBM50349213(CHEMBL1808264 | D3RKN_42)
Affinity DataKd:  370nMAssay Description:D3R2023More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2023
Entry Details
D3R

TargetAngiopoietin-1 receptor(Human)
D3R/Abbott

LigandPNGBDBM50349213(CHEMBL1808264 | D3RKN_42)
Affinity DataKd:  24nMAssay Description:D3R2025More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2023
Entry Details
D3R