BDBM50263167 3,4,5,6-Tetrahydro-2H-[1,2']bipyridinyl-4'-carboxylic acid [4'-(cyclopropylmethyl-carbamoyl)-6-methyl-biphenyl-3-yl]-amide::CHEMBL476141::D3RKN_34

SMILES Cc1ccc(NC(=O)c2ccnc(c2)N2CCCCC2)cc1-c1ccc(cc1)C(=O)NCC1CC1

InChI Key InChIKey=MDEAKINSCUXXNF-UHFFFAOYSA-N

Data  2 KI  10 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50263167   

TargetHeat shock protein beta-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263167(3,4,5,6-Tetrahydro-2H-[1,2']bipyridinyl-4'-carboxy...)
Affinity DataIC50: 6nMAssay Description:Inhibition of HSP27 phosphorylation in IL-1-alpha-stimulated HLF cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263167(3,4,5,6-Tetrahydro-2H-[1,2']bipyridinyl-4'-carboxy...)
Affinity DataIC50: 2nMAssay Description:Inhibition of p38alpha phosphorylation in IL-1-alpha-stimulated HLF cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263167(3,4,5,6-Tetrahydro-2H-[1,2']bipyridinyl-4'-carboxy...)
Affinity DataIC50: 80nMAssay Description:Inhibition of cRAFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase LCK(Mouse)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263167(3,4,5,6-Tetrahydro-2H-[1,2']bipyridinyl-4'-carboxy...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of mouse LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263167(3,4,5,6-Tetrahydro-2H-[1,2']bipyridinyl-4'-carboxy...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of LYNMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263167(3,4,5,6-Tetrahydro-2H-[1,2']bipyridinyl-4'-carboxy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263167(3,4,5,6-Tetrahydro-2H-[1,2']bipyridinyl-4'-carboxy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 10(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263167(3,4,5,6-Tetrahydro-2H-[1,2']bipyridinyl-4'-carboxy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LOKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263167(3,4,5,6-Tetrahydro-2H-[1,2']bipyridinyl-4'-carboxy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDGFR-alpha/betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263167(3,4,5,6-Tetrahydro-2H-[1,2']bipyridinyl-4'-carboxy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of p38beta/gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50263167(3,4,5,6-Tetrahydro-2H-[1,2']bipyridinyl-4'-carboxy...)
Affinity DataKd:  1.00E+4nMAssay Description:D3R2021More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2023
Entry Details
D3R

TargetTyrosine-protein kinase JAK2(Human)
D3R/Abbott

LigandPNGBDBM50263167(3,4,5,6-Tetrahydro-2H-[1,2']bipyridinyl-4'-carboxy...)
Affinity DataKd:  400nMAssay Description:D3R2022More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2023
Entry Details
D3R

TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263167(3,4,5,6-Tetrahydro-2H-[1,2']bipyridinyl-4'-carboxy...)
Affinity DataKi:  2.5nMAssay Description:Displacement of rhodamine-green labeled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263167(3,4,5,6-Tetrahydro-2H-[1,2']bipyridinyl-4'-carboxy...)
Affinity DataKi:  9nMAssay Description:Inhibition of human recombinant p38alpha-mediated ATF2 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed