BDBM50173609 CHEMBL363648::D3RKN_11::N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-yl]-benzamide::US10865384, Compound TAK-715

SMILES CCc1nc(c(s1)-c1ccnc(NC(=O)c2ccccc2)c1)-c1cccc(C)c1

InChI Key InChIKey=HEKAIDKUDLCBRU-UHFFFAOYSA-N

Data  14 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50173609   

TargetMAP/microtubule affinity-regulating kinase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173609(N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration against Mitogen-activated protein kinase kinase kinase 7 (TAK1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173609(N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-yl...)
Affinity DataIC50: 200nMAssay Description:Inhibitory concentration against mitogen-activated protein kinase p38-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173609(N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration against c-Jun N-terminal kinase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173609(N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration against Mitogen-activated protein kinase kinase kinase 1 (MEKK1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173609(N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration against I-kappa-B kinase betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 13(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173609(N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration against mitogen-activated protein kinase p38-deltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173609(N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration against mitogen-activated protein kinase 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173609(N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-yl...)
Affinity DataIC50: 7.10nMAssay Description:In vitro inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173609(N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration against mitogen-activated protein kinase p38-gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173609(N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-yl...)
Affinity DataIC50: 240nMAssay Description:Inhibition of recombinant human FLAG-tagged p38alpha expressed in baculovirus expression system using GFP-ATF2 (19 to 96 residues) as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173609(N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-yl...)
Affinity DataIC50: 240nMAssay Description:Inhibition of MAPK p38 in human THP1 cells assessed as reduction in LPS-induced TNFalpha production preincubated for 60 mins followed by LPS addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Human)
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM50173609(N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-yl...)
Affinity DataIC50: 78nMAssay Description:Table 3: Small molecules were tested for their inhibitory activities towards casein kinase 1 delta (CK1δ) and 1 epsilon (CK1ϵ). The in vit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2021
Entry Details
Go to US Patent

TargetCasein kinase I isoform epsilon(Human)
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM50173609(N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-yl...)
Affinity DataIC50: 107nMAssay Description:Table 3: Small molecules were tested for their inhibitory activities towards casein kinase 1 delta (CK1δ) and 1 epsilon (CK1ϵ). The in vit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2021
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 14(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173609(N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-yl...)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of p38 alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM50173609(N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-yl...)
Affinity DataKd:  1.00E+4nMAssay Description:D3R2021More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2023
Entry Details
D3R

TargetTyrosine-protein kinase JAK2(Human)
D3R/Abbott

LigandPNGBDBM50173609(N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-yl...)
Affinity DataKd:  2.80E+3nMAssay Description:D3R2022More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2023
Entry Details
D3R