BDBM50157526 CHEMBL586426::D3RKN_107::TCMDC-133606

SMILES COC(=O)c1cccc(NC(=O)NC2CCN(C2)c2ccnc(Nc3ccc(F)cc3)n2)c1

InChI Key InChIKey=LLVPDBRSUHNJQQ-UHFFFAOYSA-N

Data  1 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50157526   

TargetNucleosome-remodeling factor subunit BPTF(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50157526(TCMDC-133606 | CHEMBL586426 | D3RKN_107)
Affinity DataKd:  2.80E+3nMAssay Description:Binding affinity to BPTF (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetNucleosome-remodeling factor subunit BPTF(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50157526(TCMDC-133606 | CHEMBL586426 | D3RKN_107)
Affinity DataKd:  2.80E+3nMAssay Description:Binding affinity to BPTF (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetNucleosome-remodeling factor subunit BPTF(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50157526(TCMDC-133606 | CHEMBL586426 | D3RKN_107)
Affinity DataKd:  2.80E+3nMAssay Description:Binding affinity to 5FW-labelled BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells by 19F-NMR spectraMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetNucleosome-remodeling factor subunit BPTF(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50157526(TCMDC-133606 | CHEMBL586426 | D3RKN_107)
Affinity DataKd:  2.80E+3nMAssay Description:Binding affinity to 5FW-labeled BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by BODIPY-BI2536 tracer ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetCathepsin S(Human)
D3R/Abbott

LigandPNGBDBM50157526(TCMDC-133606 | CHEMBL586426 | D3RKN_107)
Affinity DataIC50: 1.00E+4nMAssay Description:D3R2024More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2023
Entry Details
D3R