BDBM410052 D2211::US10370360, Example 4

SMILES CN1CCN(Cc2cc(NC(=O)c3ccc4CCN(Cc4c3)c3cccnc3)cc(c2)C(F)(F)F)CC1

InChI Key InChIKey=SSHLZMDEQQUFCQ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 410052   

TargetEpithelial discoidin domain-containing receptor 1(Human)
University of Texas

US Patent
LigandPNGBDBM410052(D2211 | US10370360, Example 4)
Affinity DataIC50: 328nMAssay Description:The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent

TargetDiscoidin domain-containing receptor 2(Human)
University of Texas

US Patent
LigandPNGBDBM410052(D2211 | US10370360, Example 4)
Affinity DataIC50: 4.30E+3nMAssay Description:The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent

TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of Texas

US Patent
LigandPNGBDBM410052(D2211 | US10370360, Example 4)
Affinity DataIC50: 1.00E+4nMAssay Description:The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
University of Texas

US Patent
LigandPNGBDBM410052(D2211 | US10370360, Example 4)
Affinity DataIC50: 1.00E+4nMAssay Description:The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent

TargetEpithelial discoidin domain-containing receptor 1(Human)
University of Texas

US Patent
LigandPNGBDBM410052(D2211 | US10370360, Example 4)
Affinity DataIC50: 328nMAssay Description:Inhibition of human recombinant GST-tagged DDR1 (440 to 876 residues) expressed in baculovirus infected Sf9 insect cells using fluorescein-poly GAT a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM410052(D2211 | US10370360, Example 4)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human full length recombinant His-tagged ABL1 expressed in baculovirus infected Sf9 insect cells using tyrosine 2 peptide as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEpithelial discoidin domain-containing receptor 1(Human)
University of Texas

US Patent
LigandPNGBDBM410052(D2211 | US10370360, Example 4)
Affinity DataIC50: 328nMAssay Description:Inhibition of human recombinant GST-tagged DDR1 (440 to 876 residues) expressed in baculovirus infected Sf9 insect cells using fluorescein-poly GAT a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM410052(D2211 | US10370360, Example 4)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human full length recombinant His-tagged ABL1 expressed in baculovirus infected Sf9 insect cells using tyrosine 2 peptide as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed