BDBM50327696 2-(1-octyl-5-m-tolyl-1H-indol-3-yl)acetamide::CHEMBL240860::Cysmethynil

SMILES CCCCCCCCn1cc(CC(N)=O)c2cc(ccc12)-c1cccc(C)c1

InChI Key InChIKey=QIXBOOVPFRZHQQ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50327696   

TargetProtein-S-isoprenylcysteine O-methyltransferase(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50327696(2-(1-octyl-5-m-tolyl-1H-indol-3-yl)acetamide | Cys...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50327696(2-(1-octyl-5-m-tolyl-1H-indol-3-yl)acetamide | Cys...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of recombinant ICMT expressed in Sf9 cells using [3H]-AdoMet after 20 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50327696(2-(1-octyl-5-m-tolyl-1H-indol-3-yl)acetamide | Cys...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of recombinant Icmt (unknown origin) expressed in Sf9 cells assessed as transfer of methyl group from [3H]-S-adenosylmethionine to [3H]-bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50327696(2-(1-octyl-5-m-tolyl-1H-indol-3-yl)acetamide | Cys...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of recombinant ICMT (unknown origin) expressed in sf9 cells using biotin S-farnesyl-L-cysteine as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50327696(2-(1-octyl-5-m-tolyl-1H-indol-3-yl)acetamide | Cys...)
Affinity DataIC50: 2.09E+3nMAssay Description:Inhibition of ICMT expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed