BDBM50218197 (-)-beta-Sitosterol::(24R)-Ethylcholest-5-en-3beta-ol::(24R)-Stigmast-5-en-3beta-ol::(3beta)-Stigmast-5-en-3-ol::22,23-Dihydrostigmasterol::24alpha-Ethylcholesterol::Azuprostat::CHEMBL221542::Cupreol::Nimbosterol::Triastonal::alpha-Dihydrofucosterol::beta-Sitosterin::sitosterol::stigmast-5-en-3beta-ol

SMILES CC[C@H](CC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C)C(C)C

InChI Key InChIKey=KZJWDPNRJALLNS-UHFFFAOYSA-N

Data  1 KI  7 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50218197   

TargetCytochrome P450 3A4(Human)
Toyama Medical and Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50218197(stigmast-5-en-3beta-ol | sitosterol | (-)-beta-Sit...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP3A4 by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Toyama Medical and Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50218197(stigmast-5-en-3beta-ol | sitosterol | (-)-beta-Sit...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2D6 by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA polymerase beta(Human)
Virginia Polytechnic Institute and State University

Curated by ChEMBL
LigandPNGBDBM50218197(stigmast-5-en-3beta-ol | sitosterol | (-)-beta-Sit...)
Affinity DataIC50: 2.63E+4nMAssay Description:Inhibition of DNA polymerase beta lyase activity by deoxyribose phosphate excision assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
Institute of Medicinal and Aromatic Plants

Curated by ChEMBL
LigandPNGBDBM50218197(stigmast-5-en-3beta-ol | sitosterol | (-)-beta-Sit...)
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of thrombin in human platelet rich plasma assessed as reduction in thrombin-induced platelet aggregation after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Institute of Medicinal and Aromatic Plants

Curated by ChEMBL
LigandPNGBDBM50218197(stigmast-5-en-3beta-ol | sitosterol | (-)-beta-Sit...)
Affinity DataIC50: 1.50E+6nMAssay Description:Inhibition of thrombin in human platelet rich plasma assessed as reduction in arachidonic acid-induced platelet aggregation after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Institute of Medicinal and Aromatic Plants

Curated by ChEMBL
LigandPNGBDBM50218197(stigmast-5-en-3beta-ol | sitosterol | (-)-beta-Sit...)
Affinity DataIC50: 1.50E+6nMAssay Description:Inhibition of thrombin in human platelet rich plasma assessed as reduction in ADP-induced platelet aggregation after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Institute of Medicinal and Aromatic Plants

Curated by ChEMBL
LigandPNGBDBM50218197(stigmast-5-en-3beta-ol | sitosterol | (-)-beta-Sit...)
Affinity DataIC50: 9.20E+3nMAssay Description:Inhibition of thrombin in human washed platelets assessed as reduction in thrombin-induced platelet aggregation after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Institute of Medicinal and Aromatic Plants

Curated by ChEMBL
LigandPNGBDBM50218197(stigmast-5-en-3beta-ol | sitosterol | (-)-beta-Sit...)
Affinity DataKi:  267nMAssay Description:Uncompetitive inhibition of human thrombin using T1637 as substrate by Michaelis-Menten plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed