BDBM50089528 Actinomycin D::Actinomycin D analogue::Cosmegen::Dactinomycin

SMILES [H][C@@]12CCCN1C(=O)[C@H](NC(=O)[C@@H](NC(=O)c1ccc(C)c3oc4c(C)c(=O)c(N)c(C(=O)N[C@H]5[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@]6([H])CCCN6C(=O)[C@H](NC5=O)C(C)C)c4nc13)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C2=O)C(C)C

InChI Key InChIKey=RJURFGZVJUQBHK-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50089528   

TargetGrowth factor receptor-bound protein 2(Mouse)
Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL
LigandPNGBDBM50089528(Actinomycin D analogue | Actinomycin D | Cosmegen ...)
Affinity DataIC50: 5.00E+3nMAssay Description:In vitro binding assay of Shc-derived phosphopeptide to Growth factor receptor bound protein 2 SH2 in B104-1-1 cells was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Missouri

Curated by ChEMBL
LigandPNGBDBM50089528(Actinomycin D analogue | Actinomycin D | Cosmegen ...)
Affinity DataIC50: 2.70E+5nMAssay Description:Inhibition of HIV-1 reverse transcriptase using Poly(rA).p(dT) (12 to 18) as substrate after 30 mins by single point PCR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetPeptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50089528(Actinomycin D analogue | Actinomycin D | Cosmegen ...)
Affinity DataKd:  8.85E+4nMAssay Description:Binding affinity to recombinant hexa-histidine-tagged human full-length N-GLY1 catalytic domain expressed in Escherichia coli BL21 (DE3) by thermal s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed