BDBM50042978 (E)-1-(2-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one::(E)-3-(4-hydroxyphenyl)-1-(2-hydroxyphenyl)-2-propen-1-one::3-(4-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone::CHEMBL126804::Chalcone 3::US11866416, Compound SN-II-113

SMILES Oc1ccc(\C=C\C(=O)c2ccccc2O)cc1

InChI Key InChIKey=FGPJTMCJNPRZGF-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50042978   

TargetStromal cell-derived factor 1(Human)
UniversitÉ

LigandPNGBDBM50042978((E)-1-(2-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-...)
Affinity DataIC50: 2.42E+4nMT: 2°CAssay Description:Binding of chalcone 4 and chlcone 1 to CSCL12 was examined by monitoring changes in the emission intensity of intrinsic Trp fluorescence of the chemo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042978((E)-1-(2-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-...)
Affinity DataIC50: 4.20E+4nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042978((E)-1-(2-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-...)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of 5-lipoxygenase in rat RBL1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article

TargetXanthine dehydrogenase/oxidase(Bovine)
Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM50042978((E)-1-(2-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-...)
Affinity DataIC50: 7.94E+4nMAssay Description:Inhibition of bovine milk xanthine oxidase pre-incubated for 30 mins followed by xanthine addition and measured every 30 secs for 5 mins by spectroph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2020
Entry Details Article
PubMed
LigandPNGBDBM50042978((E)-1-(2-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-...)
Affinity DataIC50: 4.25E+3nMAssay Description:Inhibition of Rattus norvegicus (rat) lens aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation

US Patent
LigandPNGBDBM50042978((E)-1-(2-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-...)
Affinity DataIC50: 2.13E+5nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2024
Entry Details
Go to US Patent

TargetAmine oxidase [flavin-containing] A(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50042978((E)-1-(2-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-...)
Affinity DataIC50: 6.61E+4nMAssay Description:Inhibition of human recombinant MAO-A expressed in baculovirus-infected BTI cells using kynuramine as substrate incubated for 30 mins by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50042978((E)-1-(2-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-...)
Affinity DataIC50: 800nMAssay Description:Inhibition of human recombinant MAO-B expressed in baculovirus-infected BTI cells using kynuramine as substrate incubated for 30 mins by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed