BDBM50511658 Cb-1158::INCB-001158::Incb 001158::Incb001158::Numidargistat

SMILES C[C@H](N)C(=O)N1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O

InChI Key InChIKey=ZZJLMZYUGLJBSO-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50511658   

TargetArginase-1(Human)
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50511658(Cb-1158 | INCB-001158 | Incb 001158 | Incb001158 |...)
Affinity DataIC50: 120nMAssay Description:Inhibition of recombinant human arginase 1 using L-arginine as substrate measured after 60 mins in presence of manganese chloride by o-phthaldialdehy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetArginase-1(Human)
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50511658(Cb-1158 | INCB-001158 | Incb 001158 | Incb001158 |...)
Affinity DataIC50: 98nMAssay Description:Inhibition of human arginase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetArginase-1(Human)
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50511658(Cb-1158 | INCB-001158 | Incb 001158 | Incb001158 |...)
Affinity DataIC50: 86nMAssay Description:Inhibition of human Arg1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetArginase-2, mitochondrial(Human)
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50511658(Cb-1158 | INCB-001158 | Incb 001158 | Incb001158 |...)
Affinity DataIC50: 296nMAssay Description:Inhibition of human Arg2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetArginase-1(Human)
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50511658(Cb-1158 | INCB-001158 | Incb 001158 | Incb001158 |...)
Affinity DataIC50: 29nMAssay Description:Inhibition of human Arg IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetArginase-2, mitochondrial(Human)
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50511658(Cb-1158 | INCB-001158 | Incb 001158 | Incb001158 |...)
Affinity DataIC50: 296nMAssay Description:Inhibition of human Arg IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetArginase-1(Human)
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50511658(Cb-1158 | INCB-001158 | Incb 001158 | Incb001158 |...)
Affinity DataIC50: 86nMAssay Description:Inhibition of human recombinant ARG1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetArginase-2, mitochondrial(Human)
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50511658(Cb-1158 | INCB-001158 | Incb 001158 | Incb001158 |...)
Affinity DataIC50: 296nMAssay Description:Inhibition of recombinant human ARG2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetArginase-1(Human)
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50511658(Cb-1158 | INCB-001158 | Incb 001158 | Incb001158 |...)
Affinity DataIC50: 86nMAssay Description:Inhibition of full length recombinant human arginase 1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed