BDBM50094009 CHEMBL136800::CX-516::Piperidin-1-yl-quinoxalin-6-yl-methanone::US11718589, Compound 74b

SMILES c1cc2c(cc1C(=O)N3CCCCC3)nccn2

InChI Key InChIKey=ANDGGVOPIJEHOF-UHFFFAOYSA-N

Data  2 IC50  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50094009   

TargetGlutamate receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50094009(Piperidin-1-yl-quinoxalin-6-yl-methanone | CX-516 ...)
Affinity DataEC50:  1.56E+5nMAssay Description:Inhibition of GluR4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetGlutamate receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50094009(Piperidin-1-yl-quinoxalin-6-yl-methanone | CX-516 ...)
Affinity DataEC50: >1.00E+6nMAssay Description:Inhibition of GluR4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetGlutamate receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50094009(Piperidin-1-yl-quinoxalin-6-yl-methanone | CX-516 ...)
Affinity DataEC50: >1.00E+6nMAssay Description:Tested for potentiation towards human iGluR4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Human)
Case Western Reserve University

US Patent
LigandPNGBDBM50094009(Piperidin-1-yl-quinoxalin-6-yl-methanone | CX-516 ...)
Affinity DataIC50: 300nMAssay Description:This Example provides data on two groups (Table 1 and Table 2) of structural analogues of identified 15-PGDH inhibitors. Data provided is the IC50 of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2023
Entry Details
Go to US Patent

Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Human)
Case Western Reserve University

US Patent
LigandPNGBDBM50094009(Piperidin-1-yl-quinoxalin-6-yl-methanone | CX-516 ...)
Affinity DataIC50: 100nMAssay Description:Inhibition of 15-PGDH (unknown origin) using NAD as substrate measured for 3.5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed