BDBM50240609 2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid(CV-11974)::2-Ethoxy-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid::2-ethoxy-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid::CANDESARTAN::CHEMBL1016::CV-11974

SMILES CCOc1nc2cccc(C(O)=O)c2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1

InChI Key InChIKey=HTQMVQVXFRQIKW-UHFFFAOYSA-N

Data  8 KI  12 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50240609   

TargetType-1 angiotensin II receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50240609(CHEMBL1016 | 2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-bip...)
Affinity DataIC50: 11nMAssay Description:Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
TargetLeukotriene B4 receptor 2(Human)
Fraunhofer Institute For Translational Medicine and Phamacology Itmp

Curated by ChEMBL
LigandPNGBDBM50240609(CHEMBL1016 | 2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-bip...)
Affinity DataEC50:  1.50E+4nMAssay Description:Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetCo-chaperonin GroES(Escherichia coli)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50240609(CHEMBL1016 | 2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-bip...)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetChaperonin GroEL(Escherichia coli)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50240609(CHEMBL1016 | 2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-bip...)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of ATPase activity of Escherichia coli GroEL expressed in Escherichia coliDH5alpha incubated for 60 mins using ATP by spectrometric analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCo-chaperonin GroES(Escherichia coli)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50240609(CHEMBL1016 | 2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-bip...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
Target60 kDa heat shock protein, mitochondrial(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50240609(CHEMBL1016 | 2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-bip...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Roset...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetThiosulfate sulfurtransferase(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50240609(CHEMBL1016 | 2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-bip...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of native rhodanese (unknown origin) assessed as reduction in rhodanese enzyme activity after 45 mins by Fe(SCN)3 dye based spectrometric ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Bovine)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50240609(CHEMBL1016 | 2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-bip...)
Affinity DataIC50: 110nMAssay Description:Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50240609(CHEMBL1016 | 2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-bip...)
Affinity DataIC50: 110nMAssay Description:Binding affinity to angiotensin AT1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50240609(CHEMBL1016 | 2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-bip...)
Affinity DataIC50: 0.690nMAssay Description:Displacement of [3H]-Angiotensin 2 from human AT1 receptor transfected in CHOK1 cells preincubated for 30 mins with bovine serum albumin followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Bovine)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50240609(CHEMBL1016 | 2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-bip...)
Affinity DataIC50: 110nMAssay Description:Concentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2010
Entry Details Article

TargetType-1 angiotensin II receptor(Bovine)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50240609(CHEMBL1016 | 2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-bip...)
Affinity DataIC50: 110nMAssay Description:Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetType-1 angiotensin II receptor(Rabbit)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50240609(CHEMBL1016 | 2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-bip...)
Affinity DataIC50: 28nMAssay Description:Inhibitory activity against Angiotensin II receptor, type 1 in rabbit aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor B(Rat)
Shinshu University

Curated by PDSP Ki Database
LigandPNGBDBM50240609(CHEMBL1016 | 2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-bip...)
Affinity DataKi:  0.120nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor A(Rat)
Shinshu University

Curated by PDSP Ki Database
LigandPNGBDBM50240609(CHEMBL1016 | 2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-bip...)
Affinity DataKi:  0.120nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50240609(CHEMBL1016 | 2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-bip...)
Affinity DataKi:  0.170nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Rabbit)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50240609(CHEMBL1016 | 2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-bip...)
Affinity DataKi:  0.640nMAssay Description:Inhibitory activity against Angiotensin II receptor, type 1 in rat adrenal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50240609(CHEMBL1016 | 2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-bip...)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50240609(CHEMBL1016 | 2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-bip...)
Affinity DataKi:  10nMAssay Description:Displacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2020
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50240609(CHEMBL1016 | 2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-bip...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to type-2 angiotensin-2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2017
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Rat)
Shinshu University

Curated by PDSP Ki Database
LigandPNGBDBM50240609(CHEMBL1016 | 2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-bip...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed