BDBM50069041 (7R,9aS)-7-(4-Fluoro-phenoxymethyl)-2-(5-fluoro-pyrimidin-2-yl)-octahydro-pyrido[1,2-a]pyrazine::7-(4-Fluoro-phenoxymethyl)-2-(5-fluoro-pyrimidin-2-yl)-octahydro-pyrido[1,2-a]pyrazine (CP-293019)::CHEMBL66227::CP-293019

SMILES Fc1ccc(OC[C@@H]2CC[C@H]3CN(CCN3C2)c2ncc(F)cn2)cc1

InChI Key InChIKey=QXWNESOGWFJDFR-UHFFFAOYSA-N

Data  9 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50069041   

Target5-hydroxytryptamine receptor 1A(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069041(CP-293019 | (7R,9aS)-7-(4-Fluoro-phenoxymethyl)-2-...)
Affinity DataIC50: 180nMAssay Description:In vitro binding affinity against 5-hydroxytryptamine 1A receptor in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069041(CP-293019 | (7R,9aS)-7-(4-Fluoro-phenoxymethyl)-2-...)
Affinity DataIC50: 150nMAssay Description:In vitro binding affinity against 5-hydroxytryptamine 2A receptor in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069041(CP-293019 | (7R,9aS)-7-(4-Fluoro-phenoxymethyl)-2-...)
Affinity DataKi:  3.40nMAssay Description:In vitro binding affinity at human D4 dopamine receptor in CHO cells by [3H]spiperone displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069041(CP-293019 | (7R,9aS)-7-(4-Fluoro-phenoxymethyl)-2-...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity to human D4R assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50069041(CP-293019 | (7R,9aS)-7-(4-Fluoro-phenoxymethyl)-2-...)
Affinity DataKi:  180nMAssay Description:Inhibition of serotonin 5-HT1A receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069041(CP-293019 | (7R,9aS)-7-(4-Fluoro-phenoxymethyl)-2-...)
Affinity DataKi:  500nMAssay Description:Inhibition of serotonin 5-HT2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069041(CP-293019 | (7R,9aS)-7-(4-Fluoro-phenoxymethyl)-2-...)
Affinity DataKi: >2.00E+3nMAssay Description:In vitro binding affinity against human D3 dopamine receptor in CHO cells using [3H]spiperoneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069041(CP-293019 | (7R,9aS)-7-(4-Fluoro-phenoxymethyl)-2-...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of human dopamine D3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069041(CP-293019 | (7R,9aS)-7-(4-Fluoro-phenoxymethyl)-2-...)
Affinity DataKi: >3.31E+3nMAssay Description:In vitro binding affinity against human D2 dopamine receptor in CHO cells by [3H]spiperone displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069041(CP-293019 | (7R,9aS)-7-(4-Fluoro-phenoxymethyl)-2-...)
Affinity DataKi: >3.31E+3nMAssay Description:Inhibition of human dopamine D2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069041(CP-293019 | (7R,9aS)-7-(4-Fluoro-phenoxymethyl)-2-...)
Affinity DataKi: >3.31E+3nMAssay Description:Binding affinity to human D2R assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed