BDBM50398245 CHEMBL512901::CL-075

SMILES CCCc1nc2c(s1)c3ccccc3nc2N

InChI Key InChIKey=NFYMGJSUKCDVJR-UHFFFAOYSA-N

Data  6 EC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50398245   

TargetToll-like receptor 8(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50398245(CL-075 | CHEMBL512901)
Affinity DataEC50:  1.32E+3nMAssay Description:Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline pho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 8(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50398245(CL-075 | CHEMBL512901)
Affinity DataEC50:  800nMAssay Description:Agonist activity in TLR8 (unknown origin) expressed in HEK293 cells assessed as induction of NF-kappa activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 8(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50398245(CL-075 | CHEMBL512901)
Affinity DataEC50:  4.90E+3nMAssay Description:Agonist activity at TLR8 in human cryopreserved PBMC assessed as inhibition of IL-12p40 production measured after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 7(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50398245(CL-075 | CHEMBL512901)
Affinity DataEC50:  1.80E+4nMAssay Description:Agonist activity at TLR7 in human cryopreserved PBMC assessed as induction of IFNalpha production measured after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 7(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50398245(CL-075 | CHEMBL512901)
Affinity DataEC50:  5.48E+3nMAssay Description:Agonist activity at human TLR7 in HEK-Blue hTLR7 cells assessed as activation of NFkappaB by SEAP reporter gene based spectrophotometry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 8(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50398245(CL-075 | CHEMBL512901)
Affinity DataEC50:  1.32E+3nMAssay Description:Agonist activity at human TLR8 in HEK-Blue hTLR8 cells assessed as activation of NFkappaB by SEAP reporter gene based spectrophotometry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)