BDBM50277143 CHR 2797::CHR-2797::Tosedostat

SMILES CC(C)C[C@H]([C@H](O)C(=O)NO)C(=O)N[C@H](C(=O)OC1CCCC1)c1ccccc1

InChI Key InChIKey=FWFGIHPGRQZWIW-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50277143   

TargetPuromycin-sensitive aminopeptidase(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50277143(CHR 2797 | CHR-2797 | Tosedostat)
Affinity DataIC50: 260nMAssay Description:Inhibition of recombinant human N-terminal His6-MBP-tagged PSA expressed in Escherichia coli BL21 STAR (DE3) using 4-Ala-MNA as substrate measured fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2020
Entry Details Article
PubMed
TargetAminopeptidase N(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50277143(CHR 2797 | CHR-2797 | Tosedostat)
Affinity DataIC50: 680nMAssay Description:Inhibition of recombinant human C-terminal His10-tagged APN (Lys69 to Lys967 residues) using Ala-AMC as substrate measured for 30 mins by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2020
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM50277143(CHR 2797 | CHR-2797 | Tosedostat)
Affinity DataIC50: 190nMAssay Description:Inhibition of MMP2 (unknown origin) using QF-24 as substrate preincubated for 1 hr followed by substrate addition and measured at 1 min interval for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM50277143(CHR 2797 | CHR-2797 | Tosedostat)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of MMP9 (unknown origin) using QF-24 as substrate preincubated for 1 hr followed by substrate addition and measured at 1 min interval for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetAminopeptidase N(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50277143(CHR 2797 | CHR-2797 | Tosedostat)
Affinity DataKi:  1.18E+3nMAssay Description:Inhibition of soluble human APN ectodomain stably expressed in HEK293 GnTI(-) cells using H-Leu-NHMec as substrate preincubated for 10 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed