BDBM50413999 CGP77675::CHEMBL475584

SMILES COc1cccc(c1)-c1cn(-c2ccc(CCN3CCC(O)CC3)cc2)c2ncnc(N)c12

InChI Key InChIKey=WUPXZZWTHIZICK-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50413999   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Ankara University

LigandPNGBDBM50413999(CHEMBL475584 | CGP77675)
Affinity DataIC50: 0.400nMT: 2°CAssay Description:Kinase activity (Src-family kinases, Hck, Lyn, Fyn, and c-Src) and the effect of the molecules were determined by ProFluor Src-Family Kinase Assay Ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Ankara University

LigandPNGBDBM50413999(CHEMBL475584 | CGP77675)
Affinity DataIC50: 19.9nMAssay Description:Inhibition of c-SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Indo-Soviet Friendship College of Pharmacy (Isfcp)

Curated by ChEMBL
LigandPNGBDBM50413999(CHEMBL475584 | CGP77675)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of Lyn (unknown origin) using Src-family kinase bisamide rhodamine 110 peptide substrate after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Ankara University

LigandPNGBDBM50413999(CHEMBL475584 | CGP77675)
Affinity DataIC50: 20nMAssay Description:Inhibition of c-Src kinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Ankara University

LigandPNGBDBM50413999(CHEMBL475584 | CGP77675)
Affinity DataIC50: 20nMAssay Description:Inhibition of Src kinase (unknown origin) phosphorylation at Tyr416/419 residues incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50413999(CHEMBL475584 | CGP77675)
Affinity DataIC50: 150nMAssay Description:Inhibition of human recombinant His-tagged EGFR expressed in baculovirus using poly-Gluo-Tyr as a substrate measured after 24 hrs by western blot ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed