BDBM50088900 5,7-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine::5,7-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine::CGP-62464::CHEMBL169757

SMILES Nc1ncnc2n(cc(-c3ccccc3)c12)-c1ccccc1

InChI Key InChIKey=AFVGAHBUCVDPPI-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50088900   

TargetTyrosine-protein kinase ABL1/ABL2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50088900(5,7-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine | ...)
Affinity DataIC50: 20nMAssay Description:Tested in vitro for inhibition of non-receptor tyrosine kinase v-AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50088900(5,7-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine | ...)
Affinity DataIC50: 3.00E+3nMAssay Description:Tested for inhibition of EGF-receptor tyrosine kinase in intact cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50088900(5,7-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine | ...)
Affinity DataIC50: 5.40E+4nMAssay Description:Tested in vitro for inhibition of serine/threonine kinase Cdc2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50088900(5,7-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine | ...)
Affinity DataIC50: 100nMAssay Description:Tested for inhibition of protein tyrosine kinase c-Src phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50088900(5,7-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine | ...)
Affinity DataIC50: 500nMAssay Description:Tested in vitro for inhibition of KDR-receptor tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50088900(5,7-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine | ...)
Affinity DataIC50: 3.50E+3nMAssay Description:Tested for inhibition of protein tyrosine kinase c-Src phosphorylation in intact cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase CSK(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50088900(5,7-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine | ...)
Affinity DataIC50: 5.00E+3nMAssay Description:Tested for inhibition of protein tyrosine kinase Csk phosphorylation in intact cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50088900(5,7-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine | ...)
Affinity DataIC50: 100nMAssay Description:Inhibition of p60 c-Src tyrosine kinase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50088900(5,7-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine | ...)
Affinity DataIC50: 500nMAssay Description:Tested in vitro for inhibition of EGF-receptor tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50088900(5,7-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine | ...)
Affinity DataIC50: 100nMAssay Description:Inhibition of c-SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50088900(5,7-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine | ...)
Affinity DataIC50: 100nMAssay Description:Inhibition of c-Src kinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article