BDBM50298223 CGP-57380::CHEMBL1240885::CHEMBL576817::N-(4-fluorophenyl)-3H-pyrazolo[3,4-d]pyrimidine-3,4-diamine

SMILES Nc1ncnc2n[nH]c(Nc3ccc(F)cc3)c12

InChI Key InChIKey=UQPMANVRZYYQMD-UHFFFAOYSA-N

Data  2 KI  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50298223   

TargetAurora kinase B(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50298223(CHEMBL576817 | CHEMBL1240885 | CGP-57380 | N-(4-fl...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of Aurora B in the presence of 20uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50298223(CHEMBL576817 | CHEMBL1240885 | CGP-57380 | N-(4-fl...)
Affinity DataIC50: 870nMAssay Description:Inhibition of MNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50298223(CHEMBL576817 | CHEMBL1240885 | CGP-57380 | N-(4-fl...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of MNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50298223(CHEMBL576817 | CHEMBL1240885 | CGP-57380 | N-(4-fl...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of SGK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Human)
Weill Cornell Medical College

Curated by ChEMBL
LigandPNGBDBM50298223(CHEMBL576817 | CHEMBL1240885 | CGP-57380 | N-(4-fl...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50298223(CHEMBL576817 | CHEMBL1240885 | CGP-57380 | N-(4-fl...)
Affinity DataIC50: 510nMAssay Description:Inhibition of CK1delta in the presence of 20uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase BRSK2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50298223(CHEMBL576817 | CHEMBL1240885 | CGP-57380 | N-(4-fl...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of BRSK2 in the presence of 50uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50298223(CHEMBL576817 | CHEMBL1240885 | CGP-57380 | N-(4-fl...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of MNK2 in the presence of 50uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50298223(CHEMBL576817 | CHEMBL1240885 | CGP-57380 | N-(4-fl...)
Affinity DataIC50: 870nMAssay Description:Inhibition of MNK1 in the presence of 50uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 3(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50298223(CHEMBL576817 | CHEMBL1240885 | CGP-57380 | N-(4-fl...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of DYRK3 in the presence of 5uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase LCK(Mouse)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50298223(CHEMBL576817 | CHEMBL1240885 | CGP-57380 | N-(4-fl...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of Lck in the presence of 50uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50298223(CHEMBL576817 | CHEMBL1240885 | CGP-57380 | N-(4-fl...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of SGK1 in the presence of 20uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50298223(CHEMBL576817 | CHEMBL1240885 | CGP-57380 | N-(4-fl...)
Affinity DataKi:  880nMAssay Description:Inhibition of Mnk2 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2016
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50298223(CHEMBL576817 | CHEMBL1240885 | CGP-57380 | N-(4-fl...)
Affinity DataKi:  1.01E+3nMAssay Description:Inhibition of Mnk1 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2016
Entry Details Article
PubMed