BDBM50237622 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-::4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amine::CCT128930::CHEMBL263664::US8796293, 17

SMILES NC1(Cc2ccc(Cl)cc2)CCN(CC1)c1ncnc2[nH]ccc12

InChI Key InChIKey=RZIDZIGAXXNODG-UHFFFAOYSA-N

Data  22 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50237622   

TargetCytochrome P450 2C19(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50237622(US8796293, 17 | 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 in human microsomal preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50237622(US8796293, 17 | 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human PKBbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCytochrome P450 2E1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50237622(US8796293, 17 | 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2E1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50237622(US8796293, 17 | 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50237622(US8796293, 17 | 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2...)
Affinity DataIC50: 6nMAssay Description:Inhibition of PKBbeta recombinant by radiometric filter binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50237622(US8796293, 17 | 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2...)
Affinity DataIC50: 660nMAssay Description:Inhibition of GSK3-beta in human PC3M cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50237622(US8796293, 17 | 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2...)
Affinity DataIC50: 120nMAssay Description:Inhibition of p70S6K by radiometric filter binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50237622(US8796293, 17 | 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50237622(US8796293, 17 | 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50237622(US8796293, 17 | 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50237622(US8796293, 17 | 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
The Institute of Cancer Research

US Patent
LigandPNGBDBM50237622(US8796293, 17 | 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2...)
Affinity DataIC50: 1.00E+3nMpH: 7.5 T: 2°CAssay Description:In a final reaction volume of 25 ul, ROCK-II (h) (5-10 mU) is incubated with 50 mM Tris pH 7.5, 0.1 mM EGTA, 30 uM KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
Go to US Patent

TargetCytochrome P450 2C9(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50237622(US8796293, 17 | 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human microsomal preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50237622(US8796293, 17 | 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human microsomal preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50237622(US8796293, 17 | 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human microsomal preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50237622(US8796293, 17 | 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2...)
Affinity DataIC50: 6nMAssay Description:Inhibition of PKBbeta by radiometric filter binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50237622(US8796293, 17 | 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2...)
Affinity DataIC50: 3nMAssay Description:Inhibition of PKB in human PC3M cells assessed as GSK3-beta phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50237622(US8796293, 17 | 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2...)
Affinity DataIC50: 0.660nMAssay Description:Inhibition of PKB in human U87MG cells assessed as GSK3-beta phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50237622(US8796293, 17 | 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2...)
Affinity DataIC50: 660nMAssay Description:Inhibition of CYP2D6 in human microsomal preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50237622(US8796293, 17 | 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of GSK3-beta in human PC3M cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCytochrome P450 2A6(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50237622(US8796293, 17 | 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2A6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase [E49C,C296S,C310S,C344S](Human)
Technische Universit������T Dortmund

LigandPNGBDBM50237622(US8796293, 17 | 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2...)
Affinity DataIC50: 29nMAssay Description:IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturer’s instructions. The kinases A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2015
Entry Details Article
PubMed