BDBM14152 6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-CARBOXAMIDINE::APC-10302::CA-14::CRA-10302::{amino[6-chloro-2-(2-hydroxy-3-phenylphenyl)-1H-indol-5-yl]methylidene}azanium

SMILES NC(=[NH2+])c1cc2cc([nH]c2cc1Cl)-c1cccc(-c2ccccc2)c1O

InChI Key InChIKey=FEKRWNWZMOSVBX-UHFFFAOYSA-O

Data  14 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 14152   

TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceutical

LigandPNGBDBM14152(CA-14 | 6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-IN...)
Affinity DataKi:  9nM ΔG°:  -10.9kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceutical

LigandPNGBDBM14152(CA-14 | 6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-IN...)
Affinity DataKi:  13nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceutical

LigandPNGBDBM14152(CA-14 | 6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-IN...)
Affinity DataKi:  14nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2007
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Celera

LigandPNGBDBM14152(CA-14 | 6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-IN...)
Affinity DataKi:  100nM ΔG°:  -9.45kcal/molepH: 7.72 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetPlasminogen(Human)
Axys Pharmaceutical

LigandPNGBDBM14152(CA-14 | 6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-IN...)
Affinity DataKi:  110nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Celera

LigandPNGBDBM14152(CA-14 | 6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-IN...)
Affinity DataKi:  230nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Celera

LigandPNGBDBM14152(CA-14 | 6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-IN...)
Affinity DataKi:  770nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Celera

LigandPNGBDBM14152(CA-14 | 6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-IN...)
Affinity DataKi:  1.80E+3nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2007
Entry Details Article
PubMed
LigandPNGBDBM14152(CA-14 | 6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-IN...)
Affinity DataKi:  2.40E+3nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2007
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Axys Pharmaceutical

LigandPNGBDBM14152(CA-14 | 6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-IN...)
Affinity DataKi:  8.80E+3nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Axys Pharmaceutical

LigandPNGBDBM14152(CA-14 | 6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-IN...)
Affinity DataKi:  1.90E+4nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Axys Pharmaceutical

LigandPNGBDBM14152(CA-14 | 6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-IN...)
Affinity DataKi:  2.40E+4nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed
TargetProthrombin(Human)
Axys Pharmaceutical

LigandPNGBDBM14152(CA-14 | 6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-IN...)
Affinity DataKi:  6.00E+4nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed
TargetProthrombin(Human)
Axys Pharmaceutical

LigandPNGBDBM14152(CA-14 | 6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-IN...)
Affinity DataKi:  8.50E+4nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2007
Entry Details Article
PubMed