BDBM85484 Bombesin

SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)N1)C(C)C)C(N)=O

InChI Key InChIKey=QXZBMSIDSOZZHK-UHFFFAOYSA-N

Data  12 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 85484   

TargetNeuropeptide Y receptor type 1(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM85484(Bombesin)
Affinity DataIC50: 4.70nMAssay Description:Displacement of [125I]-NPY from Y1 receptor in human MCF7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM85484(Bombesin)
Affinity DataIC50: 2nMAssay Description:Displacement of [125I]-Tyr4-BBN from human GRPR overexpressed in human T47D cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM85484(Bombesin)
Affinity DataEC50:  0.258nMAssay Description:Displacement of 125I[Tyr4]-bombesin from GRPR expressed in human PC3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM85484(Bombesin)
Affinity DataKi:  0.150nMAssay Description:Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human GRP(gastrin releasing peptide) receptors stably expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetGastrin-releasing peptide receptor(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM85484(Bombesin)
Affinity DataKi:  0.150nMAssay Description:In vitro binding affinity at Bombesin BB2 receptor in the presence of [125I]-[Tyr] bombesin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Mouse)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database
LigandPNGBDBM85484(Bombesin)
Affinity DataKi:  1.24nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Mouse)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database
LigandPNGBDBM85484(Bombesin)
Affinity DataKi:  1.31nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Mouse)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database
LigandPNGBDBM85484(Bombesin)
Affinity DataKi:  1.32nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Mouse)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database
LigandPNGBDBM85484(Bombesin)
Affinity DataKi:  1.76nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
TargetNeuromedin-B receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM85484(Bombesin)
Affinity DataKi:  2nMAssay Description:Binding affinity against human NMB receptor was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetNeuromedin-B receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM85484(Bombesin)
Affinity DataKi:  2nMAssay Description:Antagonistic activity against labelled Bombesin receptor bb1 binding sites in rat olfactory bulb by using [125I]- [Tyr] bombesin in presence of [D-Ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database
LigandPNGBDBM85484(Bombesin)
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
TargetBombesin(frogs and toads)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database
LigandPNGBDBM85484(Bombesin)
Affinity DataKi:  14nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
TargetNeuromedin-B receptor(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database
LigandPNGBDBM85484(Bombesin)
Affinity DataKi:  34nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
TargetBombesin receptor subtype-3(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by PDSP Ki Database
LigandPNGBDBM85484(Bombesin)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed