BDBM50578294 Bms 813160::Bms-813160

SMILES CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@H](Nc2ncnc3cc(nn23)C(C)(C)C)C1=O)NC(C)(C)C

InChI Key InChIKey=CMVHFGNTABZQJU-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50578294   

TargetC-C chemokine receptor type 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50578294(Bms 813160 | Bms-813160)
Affinity DataIC50: 6.20nMAssay Description:Displacement of [125I]-CCL2 from CCR2 in human PBMC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50578294(Bms 813160 | Bms-813160)
Affinity DataIC50: 0.800nMAssay Description:Antagonist activity at CCR2 in human THP-1 cells assessed as reduction in CCL2-induced chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50578294(Bms 813160 | Bms-813160)
Affinity DataIC50: 4.80nMAssay Description:Antagonist activity at CCR2 in human whole blood assessed as inhibition of CCL2-induced CD11b upregulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50578294(Bms 813160 | Bms-813160)
Affinity DataIC50: 3.60nMAssay Description:Displacement of [125I]MIP-1beta from CCR5 in human peripheral T cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50578294(Bms 813160 | Bms-813160)
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at CCR5 in human peripheral T cells assessed as reduction in MIP-1beta-induced chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50578294(Bms 813160 | Bms-813160)
Affinity DataIC50: 5.70nMAssay Description:Antagonist activity at CCR5 in human whole blood assessed as inhibition of MIP-1beta-induced CD11b upregulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50578294(Bms 813160 | Bms-813160)
Affinity DataIC50: 2.50E+4nMAssay Description:Displacement of [125I]MIP-1alpha from CCR1 in human THP-1 cells incubated for 12 hrs by radioligand competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50578294(Bms 813160 | Bms-813160)
Affinity DataIC50: 4.00E+4nMAssay Description:Displacement of [125I]chemokine from CCR4 (unknown origin) by gamma counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50578294(Bms 813160 | Bms-813160)
Affinity DataIC50: 4.00E+4nMAssay Description:Displacement of [125I]-interleukin-8 from human CXCR2 expressed in human pEAK rapid cells incubated for 90 mins by microscintillation counting analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Mouse)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50578294(Bms 813160 | Bms-813160)
Affinity DataIC50: 45nMAssay Description:Displacement of [125I]-CCL2 from mouse CCR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed