BDBM50241654 (+)-berbamine::Berbamine::CHEMBL504323

SMILES COc1cc2CCN(C)[C@H]3Cc4ccc(Oc5cc(C[C@H]6N(C)CCc7cc(OC)c(OC)c(Oc1cc23)c67)ccc5O)cc4

InChI Key InChIKey=DFOCUWZXJBAUSQ-UHFFFAOYSA-N

Data  2 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50241654   

LigandPNGBDBM50241654((+)-berbamine | Berbamine | CHEMBL504323)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of calmodulin-dependent phosphodiesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Institut Pasteur Korea

LigandPNGBDBM50241654((+)-berbamine | Berbamine | CHEMBL504323)
Affinity DataIC50: 7.87E+3nMAssay Description:Ten-point DRCs were generated for each drug. Vero cells were seeded at 1.2 × 104 cells per well in DMEM, supplemented with 2% FBS and 1× ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details Article
PubMed
TargetCholinesterase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50241654((+)-berbamine | Berbamine | CHEMBL504323)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human BuChE using butyrylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50241654((+)-berbamine | Berbamine | CHEMBL504323)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50241654((+)-berbamine | Berbamine | CHEMBL504323)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of POP (unknown origin) using (Z)-Gly-Pro-p-nitroanilide as substrate preincubated for 5 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50241654((+)-berbamine | Berbamine | CHEMBL504323)
Affinity DataKi:  284nMAssay Description:Displacement of [125I]apamin from human SK2 expressed in HEK293 cells assessed as inhibition constant incubated for 1 hr by liquid scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
LigandPNGBDBM50241654((+)-berbamine | Berbamine | CHEMBL504323)
Affinity DataKi:  679nMAssay Description:Displacement of [125I]apamin from human SK3 expressed in HEK293 cells assessed as inhibition constant incubated for 1 hr by liquid scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed