BDBM50208999 (R)-1-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenyl)urea::(R)-1-(5-chloro-2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)phenyl)urea::BX-471::BX-741::CHEMBL232656

SMILES C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1NC(N)=O

InChI Key InChIKey=XQYASZNUFDVMFH-UHFFFAOYSA-N

Data  1 KI  10 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50208999   

TargetC-C chemokine receptor type 1(Human)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50208999(BX-741 | BX-471 | (R)-1-(5-chloro-2-(2-(4-(4-fluor...)
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Mouse)
Tanabe Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50208999(BX-741 | BX-471 | (R)-1-(5-chloro-2-(2-(4-(4-fluor...)
Affinity DataIC50: 615nMAssay Description:Binding affinity at mouse CCR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50208999(BX-741 | BX-471 | (R)-1-(5-chloro-2-(2-(4-(4-fluor...)
Affinity DataIC50: 18nMAssay Description:Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50208999(BX-741 | BX-471 | (R)-1-(5-chloro-2-(2-(4-(4-fluor...)
Affinity DataIC50: 31nMAssay Description:Binding Affinity at CCL3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMacrophage inflammatory protein-1 alpha receptor(Rat)
Tanabe Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50208999(BX-741 | BX-471 | (R)-1-(5-chloro-2-(2-(4-(4-fluor...)
Affinity DataIC50: 59nMAssay Description:Binding affinity at rat CCR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50208999(BX-741 | BX-471 | (R)-1-(5-chloro-2-(2-(4-(4-fluor...)
Affinity DataIC50: 18nMAssay Description:Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50208999(BX-741 | BX-471 | (R)-1-(5-chloro-2-(2-(4-(4-fluor...)
Affinity DataIC50: 5.5nMAssay Description:Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Mouse)
Tanabe Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50208999(BX-741 | BX-471 | (R)-1-(5-chloro-2-(2-(4-(4-fluor...)
Affinity DataKd:  200nMAssay Description:Binding affinity to mouse CCR1 by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50208999(BX-741 | BX-471 | (R)-1-(5-chloro-2-(2-(4-(4-fluor...)
Affinity DataKd:  1nMAssay Description:Binding affinity to human CCR1 by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50208999(BX-741 | BX-471 | (R)-1-(5-chloro-2-(2-(4-(4-fluor...)
Affinity DataIC50: 1.30nMAssay Description:Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50208999(BX-741 | BX-471 | (R)-1-(5-chloro-2-(2-(4-(4-fluor...)
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50208999(BX-741 | BX-471 | (R)-1-(5-chloro-2-(2-(4-(4-fluor...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant CCR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetC-C chemokine receptor type 1(Human)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50208999(BX-741 | BX-471 | (R)-1-(5-chloro-2-(2-(4-(4-fluor...)
Affinity DataKi:  1nMAssay Description:Binding affinity to CCR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed