BDBM16981 BX-201::[(3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-indol-5-yl]urea::indolinone based inhibitor, 3l

SMILES NC(=O)Nc1ccc2NC(=O)\C(=C/c3ccc[nH]3)c2c1

InChI Key InChIKey=SOVOJYOIAXOTIM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 16981   

Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM16981(indolinone based inhibitor, 3l | [(3Z)-2-oxo-3-(1H...)
Affinity DataIC50: 20nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM16981(indolinone based inhibitor, 3l | [(3Z)-2-oxo-3-(1H...)
Affinity DataIC50: 18nMAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Human)
Indian Institute of Technology (B.H.U.)

Curated by ChEMBL
LigandPNGBDBM16981(indolinone based inhibitor, 3l | [(3Z)-2-oxo-3-(1H...)
Affinity DataIC50: 20nMAssay Description:Inhibition of PDK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed