BDBM10904 1-[(benzyloxy)methyl]-5-methyl-6-(phenylsulfanyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione::1-[(benzyloxy)methyl]-6-(phenylthio)-thymine::BPT::CHEMBL37067

SMILES Cc1c(Sc2ccccc2)n(COCc2ccccc2)c(=O)[nH]c1=O

InChI Key InChIKey=FJOBRMRZIMEZQZ-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 10904   

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Université

Curated by ChEMBL
LigandPNGBDBM10904(1-[(benzyloxy)methyl]-6-(phenylthio)-thymine | CHE...)
Affinity DataEC50:  88nMAssay Description:Inhibitory concentration against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Université

Curated by ChEMBL
LigandPNGBDBM10904(1-[(benzyloxy)methyl]-6-(phenylthio)-thymine | CHE...)
Affinity DataEC50:  88nMAssay Description:Inhibition of HIV-1 reverse transcriptase at 37 degree CentigradeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Institut Curie

LigandPNGBDBM10904(1-[(benzyloxy)methyl]-6-(phenylthio)-thymine | CHE...)
Affinity DataIC50: 300nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2006
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Université

Curated by ChEMBL
LigandPNGBDBM10904(1-[(benzyloxy)methyl]-6-(phenylthio)-thymine | CHE...)
Affinity DataIC50: 400nMAssay Description:Inhibition of HIV-1 reverse transcriptase (RT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed