BDBM50031845 (4-Biphenyl-4-yl-1-phosphono-butyl)-phosphonic acid::BPH-674::CHEMBL87292

SMILES OP(O)(=O)C(CCCc1ccc(cc1)-c1ccccc1)P(O)(O)=O

InChI Key InChIKey=UQVFFWAGEQWWMP-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50031845   

TargetDecaprenyl diphosphate synthase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of California San Diego

LigandPNGBDBM50031845((4-Biphenyl-4-yl-1-phosphono-butyl)-phosphonic aci...)
Affinity DataIC50: 1.60E+3nMpH: 7.5Assay Description:We screened an in-house library of 53 compounds using trans-FPP as substrate. Briefly, the condensation of IPP and GPP, FPP, or cis-FPP catalyzed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031845((4-Biphenyl-4-yl-1-phosphono-butyl)-phosphonic aci...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition rat liver microsomal squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50031845((4-Biphenyl-4-yl-1-phosphono-butyl)-phosphonic aci...)
Affinity DataIC50: 0.700nMAssay Description:Inhibitory activity against rat liver microsomal squalene synthase was determined using [3H]FPP as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target4,4'-diapophytoene synthase(Staphylococcus aureus)
Guru Nanak Dev University

Curated by ChEMBL
LigandPNGBDBM50031845((4-Biphenyl-4-yl-1-phosphono-butyl)-phosphonic aci...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of Staphylococcus aureus CrtMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed