BDBM25266 BPH-628::bisphosphonate, 21::{1-hydroxy-2-[3-(4-phenylphenyl)phenyl]-1-phosphonoethyl}phosphonic acid

SMILES OC(Cc1cccc(c1)-c1ccc(cc1)-c1ccccc1)(P(O)(O)=O)P(O)(O)=O

InChI Key InChIKey=MPBUFKZCEBTBSK-UHFFFAOYSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 25266   

TargetGeranylgeranyl pyrophosphate synthase(Human)
National Taiwan University

LigandPNGBDBM25266({1-hydroxy-2-[3-(4-phenylphenyl)phenyl]-1-phosphon...)
Affinity DataIC50: 720nMpH: 7.0 T: 2°CAssay Description:The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2008
Entry Details Article
PubMed
TargetDecaprenyl diphosphate synthase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of California San Diego

LigandPNGBDBM25266({1-hydroxy-2-[3-(4-phenylphenyl)phenyl]-1-phosphon...)
Affinity DataIC50: 3.10E+4nMpH: 7.5Assay Description:We screened an in-house library of 53 compounds using trans-FPP as substrate. Briefly, the condensation of IPP and GPP, FPP, or cis-FPP catalyzed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details Article
PubMed
TargetGeranylgeranyl pyrophosphate synthase(Human)
National Taiwan University

LigandPNGBDBM25266({1-hydroxy-2-[3-(4-phenylphenyl)phenyl]-1-phosphon...)
Affinity DataIC50: 720nMAssay Description:Inhibition of human GGPPSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGeranylgeranyl pyrophosphate synthase BTS1(Baker's yeast)
Institute of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25266({1-hydroxy-2-[3-(4-phenylphenyl)phenyl]-1-phosphon...)
Affinity DataIC50: 70nMAssay Description:Inhibition of Saccharomyces cerevisiae GGPPSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGeranylgeranyl pyrophosphate synthase(Human)
National Taiwan University

LigandPNGBDBM25266({1-hydroxy-2-[3-(4-phenylphenyl)phenyl]-1-phosphon...)
Affinity DataKi:  20nMAssay Description:Binding affinity to human GGPPSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGeranylgeranyl pyrophosphate synthase BTS1(Baker's yeast)
Institute of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25266({1-hydroxy-2-[3-(4-phenylphenyl)phenyl]-1-phosphon...)
Affinity DataKi:  30nMAssay Description:Binding affinity to Saccharomyces cerevisiae GGPPSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed