BDBM50014354 6-[4,4-Bis-(4-fluoro-phenyl)-3-(1-methyl-1H-tetrazol-5-yl)-buta-1,3-dienyl]-4-hydroxy-tetrahydro-pyran-2-one::6-[4,4-Bis-(4-fluoro-phenyl)-3-(1-methyl-1H-tetrazol-5-yl)-buta-1,3-dienyl]-4-hydroxy-tetrahydro-pyran-2-one (BMY 22089)::BMY-22089::CHEMBL60218

SMILES [#6]-n1nnnc1\[#6](\[#6]=[#6]\[#6@@H]-1-[#6]-[#6@@H](-[#8])-[#6]-[#6](=O)-[#8]1)=[#6](/c1ccc(F)cc1)-c1ccc(F)cc1

InChI Key InChIKey=LVJIAFKNLANVJD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50014354   

LigandPNGBDBM50014354(6-[4,4-Bis-(4-fluoro-phenyl)-3-(1-methyl-1H-tetraz...)
Affinity DataIC50: 43nMAssay Description:In vitro inhibition of rat liver microsomal HMG-CoA reductase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014354(6-[4,4-Bis-(4-fluoro-phenyl)-3-(1-methyl-1H-tetraz...)
Affinity DataIC50: 24nMAssay Description:In vitro inhibitory activity was measured against rat liver HMG-CoA reductase using [2-14C]-acetate incorporationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed