BDBM50228465 1-(4-benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione::BMS-488043::CHEMBL238103

SMILES COc1cnc(OC)c2[nH]cc(C(=O)C(=O)N3CCN(CC3)C(=O)c3ccccc3)c12

InChI Key InChIKey=DBPMWRYLTBNCCE-UHFFFAOYSA-N

Data  7 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50228465   

TargetCytochrome P450 1A2(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50228465(BMS-488043 | 1-(4-benzoylpiperazin-1-yl)-2-(4,7-di...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of recombinant CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50228465(BMS-488043 | 1-(4-benzoylpiperazin-1-yl)-2-(4,7-di...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of recombinant CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50228465(BMS-488043 | 1-(4-benzoylpiperazin-1-yl)-2-(4,7-di...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50228465(BMS-488043 | 1-(4-benzoylpiperazin-1-yl)-2-(4,7-di...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of recombinant CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50228465(BMS-488043 | 1-(4-benzoylpiperazin-1-yl)-2-(4,7-di...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of recombinant CYP3A4 using benzyloxy-4-(trifluoromethyl)coumarin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50228465(BMS-488043 | 1-(4-benzoylpiperazin-1-yl)-2-(4,7-di...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of recombinant CYP3A4 using 7-benzyloxyresorufin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50228465(BMS-488043 | 1-(4-benzoylpiperazin-1-yl)-2-(4,7-di...)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of human ERG by channel flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50228465(BMS-488043 | 1-(4-benzoylpiperazin-1-yl)-2-(4,7-di...)
Affinity DataKd:  19nMAssay Description:Inhibition of [3H]BMS-488043 binding to HIV-1 JRFL gp120 after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2020
Entry Details Article
PubMed