BDBM50088178 BMS-433771::CHEMBL243876

SMILES c1ccc2c(c1)nc(n2CCCCO)CN3c4cnccc4N(C3=O)C5CC5

InChI Key InChIKey=KSHJXDWYTZJUEI-UHFFFAOYSA-N

Data  3 IC50  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50088178   

TargetCytochrome P450 3A4(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50088178(BMS-433771 | CHEMBL243876)
Affinity DataIC50: 2.75E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50088178(BMS-433771 | CHEMBL243876)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50088178(BMS-433771 | CHEMBL243876)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetFusion glycoprotein F0(Human respiratory syncytial virus)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50088178(BMS-433771 | CHEMBL243876)
Affinity DataEC50:  28nMAssay Description:Inhibition of Respiratory syncytial virus Long fusion glycoprotein infected in Hep2 cells assessed as reduction in virus-induced cytopathic effect af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFusion glycoprotein F0(Human respiratory syncytial virus)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50088178(BMS-433771 | CHEMBL243876)
Affinity DataEC50:  20nMAssay Description:Inhibition of RSV long strain fusion protein infected in Hep2 cells assessed as reduction in virus-induced cytopathic effect after 5 days by CCK8 ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFusion glycoprotein F0(Human respiratory syncytial virus)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50088178(BMS-433771 | CHEMBL243876)
Affinity DataEC50:  7.90nMAssay Description:Inhibition of GFP-fused RSV 224 fusion protein infected in human HeLa cells assessed as reduction in viral replication after 3 days by laser microsco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)