BDBM50477339 BMS-299897::CHEMBL247471

SMILES C[C@@H](N(c1cc(F)ccc1F)S(=O)(=O)c1ccc(Cl)cc1)c1ccc(F)cc1CCCC(O)=O

InChI Key InChIKey=IZAOBRWCUGOKNH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50477339   

TargetPresenilin-1(Human)
Darmstadt University of Technology

Curated by ChEMBL
LigandPNGBDBM50477339(BMS-299897 | CHEMBL247471)
Affinity DataIC50: 7.10nMAssay Description:Effect on gamma-secretase activity in human H4 cells expressing APP695 assessed as reduction of Amyloid beta42 formation LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Darmstadt University of Technology

Curated by ChEMBL
LigandPNGBDBM50477339(BMS-299897 | CHEMBL247471)
Affinity DataIC50: 2.56E+4nMAssay Description:Displacement of [3H]L685458 from gamma-secretase in human THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Darmstadt University of Technology

Curated by ChEMBL
LigandPNGBDBM50477339(BMS-299897 | CHEMBL247471)
Affinity DataIC50: 12nMAssay Description:Displacement of [3H]IN973 from gamma-secretase in human THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Darmstadt University of Technology

Curated by ChEMBL
LigandPNGBDBM50477339(BMS-299897 | CHEMBL247471)
Affinity DataIC50: 12nMAssay Description:Inhibition of gamma secretase (unknown origin) assessed as reduction in amyloid beta levels by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed