BDBM50056404 3-Isopropyl-2-oxo-2,3-dihydro-benzoimidazole-1-carboxylic acid (8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-amide::BIMU 8::CHEMBL59834

SMILES CC(C)n1c2ccccc2n(C(=O)NC2CC3CCC(C2)N3C)c1=O

InChI Key InChIKey=AFOFVIBWSLOHFR-UHFFFAOYSA-N

Data  17 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50056404   

Target5-hydroxytryptamine receptor 4(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50056404(BIMU 8 | CHEMBL59834 | 3-Isopropyl-2-oxo-2,3-dihyd...)
Affinity DataEC50:  13nMAssay Description:Tested for its agonist potency against the 5-hydroxytryptamine 4 receptor located in the rat esophageal tunica muscularis mucosaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article

Target5-hydroxytryptamine receptor 4(Guinea pig)
Cnrs-Biocis

Curated by ChEMBL
LigandPNGBDBM50056404(BIMU 8 | CHEMBL59834 | 3-Isopropyl-2-oxo-2,3-dihyd...)
Affinity DataEC50:  43nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
LigandPNGBDBM50056404(BIMU 8 | CHEMBL59834 | 3-Isopropyl-2-oxo-2,3-dihyd...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory concentration against 5-hydroxytryptamine 3 receptor in rat entorhinal cortex using [3H]-LY 278584 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Guinea pig)
Syntex Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM50056404(BIMU 8 | CHEMBL59834 | 3-Isopropyl-2-oxo-2,3-dihyd...)
Affinity DataKi:  0.780nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 3A(Rat)
Syntex Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM50056404(BIMU 8 | CHEMBL59834 | 3-Isopropyl-2-oxo-2,3-dihyd...)
In Depth
Date in BDB:
1/2/2012
Entry Details
PubMed
LigandPNGBDBM50056404(BIMU 8 | CHEMBL59834 | 3-Isopropyl-2-oxo-2,3-dihyd...)
Affinity DataKi:  1.60nMAssay Description:Tested for its binding affinity by measuring its ability to displace [3H]granisetron from 5-hydroxytryptamine 3 receptor in rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article

Target5-hydroxytryptamine receptor 4(Guinea pig)
Cnrs-Biocis

Curated by ChEMBL
LigandPNGBDBM50056404(BIMU 8 | CHEMBL59834 | 3-Isopropyl-2-oxo-2,3-dihyd...)
Affinity DataKi:  12.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50056404(BIMU 8 | CHEMBL59834 | 3-Isopropyl-2-oxo-2,3-dihyd...)
Affinity DataKi:  15.8nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50056404(BIMU 8 | CHEMBL59834 | 3-Isopropyl-2-oxo-2,3-dihyd...)
Affinity DataKi:  19.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Guinea pig)
Syntex Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM50056404(BIMU 8 | CHEMBL59834 | 3-Isopropyl-2-oxo-2,3-dihyd...)
Affinity DataKi:  20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 3A(Guinea pig)
Syntex Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM50056404(BIMU 8 | CHEMBL59834 | 3-Isopropyl-2-oxo-2,3-dihyd...)
Affinity DataKi:  20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Cnrs-Biocis

Curated by ChEMBL
LigandPNGBDBM50056404(BIMU 8 | CHEMBL59834 | 3-Isopropyl-2-oxo-2,3-dihyd...)
Affinity DataKi:  25.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Cnrs Upr 9023

Curated by PDSP Ki Database
LigandPNGBDBM50056404(BIMU 8 | CHEMBL59834 | 3-Isopropyl-2-oxo-2,3-dihyd...)
Affinity DataKi:  45.7nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50056404(BIMU 8 | CHEMBL59834 | 3-Isopropyl-2-oxo-2,3-dihyd...)
Affinity DataKi:  50.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Cnrs-Biocis

Curated by ChEMBL
LigandPNGBDBM50056404(BIMU 8 | CHEMBL59834 | 3-Isopropyl-2-oxo-2,3-dihyd...)
Affinity DataKi:  64nMAssay Description:Binding affinity against 5-hydroxytryptamine 4 receptor in guinea pig striatum using [3H]GR-113808 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50056404(BIMU 8 | CHEMBL59834 | 3-Isopropyl-2-oxo-2,3-dihyd...)
Affinity DataKi:  79.4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50056404(BIMU 8 | CHEMBL59834 | 3-Isopropyl-2-oxo-2,3-dihyd...)
Affinity DataKi:  257nMAssay Description:Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Guinea pig)
Syntex Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM50056404(BIMU 8 | CHEMBL59834 | 3-Isopropyl-2-oxo-2,3-dihyd...)
Affinity DataKi:  1.26E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 3A(Guinea pig)
Syntex Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM50056404(BIMU 8 | CHEMBL59834 | 3-Isopropyl-2-oxo-2,3-dihyd...)
Affinity DataKi:  6.92E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details
PubMed