BDBM8436 2-[(5Z)-5-(furan-2-ylmethylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid::BI-9B9b::Rhodanine analogue

SMILES OC(=O)CN1C(=S)S\C(=C/c2ccco2)C1=O

InChI Key InChIKey=DFCZJGAFQKNSEX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 8436   

TargetLethal factor(Bacillus anthracis)
Burnham Institute For Medical Research

LigandPNGBDBM8436(2-[(5Z)-5-(furan-2-ylmethylidene)-4-oxo-2-sulfanyl...)
Affinity DataIC50: 1.40E+5nMAssay Description:Fluorescence peptide cleavage assay was performed in a 96-well plate. Each reaction contained MAPKKide, LF, and the small-molecule inhibitor. The C-t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2006
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Nas of Ukraine

Curated by ChEMBL
LigandPNGBDBM8436(2-[(5Z)-5-(furan-2-ylmethylidene)-4-oxo-2-sulfanyl...)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetLethal factor(Bacillus anthracis)
Burnham Institute For Medical Research

LigandPNGBDBM8436(2-[(5Z)-5-(furan-2-ylmethylidene)-4-oxo-2-sulfanyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Bacillus anthracis anthrax lethal factor using MAPKKide as substrate incubated for 30 mins by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed