BDBM50504654 AZL 0 211089::AZL O 211089::AZL-0211089::AZL-O-211089::BG 00012::BG 12::BG-00012::BG-12::BG00012::CHEBI:76004::Dimethyl fumar::Dimethyl fumarate::FAG-201::FP-187::FP187::Fumaric acid dimethyl ester::LAS-41008::Las41008::NSC-167432::NSC-25942::Tecfidera

SMILES COC(=O)/C=C/C(=O)OC

InChI Key InChIKey=LDCRTTXIJACKKU-UHFFFAOYSA-N

Data  1 IC50  4 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50504654   

TargetNuclear factor erythroid 2-related factor 2(Human)
Korea Institute of Science & Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50504654(CHEBI:76004 | AZL 0 211089 | AZL O 211089 | AZL-02...)
Affinity DataEC50:  5.11E+3nMAssay Description:Activation of NRF2 in human U2OS cells co-expressing Keap1 (unknown origin) assessed as induction of NRF2 translocation to nucleus incubated for 6 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50504654(CHEBI:76004 | AZL 0 211089 | AZL O 211089 | AZL-02...)
Affinity DataEC50:  3.16E+5nMAssay Description:Inhibition of tetracyclin/Dox-inducible N-terminal 3xFLAG/C-terminal GFP tagged human TET1 catalytic domain (1481 to 2136 residues) expressed in huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50504654(CHEBI:76004 | AZL 0 211089 | AZL O 211089 | AZL-02...)
Affinity DataIC50: 2.25E+5nMAssay Description:Inhibition of human recombinant RSK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Korea Institute of Science & Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50504654(CHEBI:76004 | AZL 0 211089 | AZL O 211089 | AZL-02...)
Affinity DataEC50:  7.93E+3nMAssay Description:Activation of Nrf2 in human PathHunter U2OS Keap1-Nrf2 cells assessed as Nrf2 nuclear translocation by chemiluminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Korea Institute of Science & Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50504654(CHEBI:76004 | AZL 0 211089 | AZL O 211089 | AZL-02...)
Affinity DataEC50:  5.11E+3nMAssay Description:Activation of Nrf2 in human U2OS cells co-expressing Keap1 assessed as induction of Nrf2 nuclear translocation incubated for 6 hrs by PathHunter chem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed