BDBM50249298 BEVYXXA::CHEMBL512351::N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide::betrixaban

SMILES COc1ccc(NC(=O)c2ccc(cc2)C(=N)N(C)C)c(c1)C(=O)Nc1ccc(Cl)cn1

InChI Key InChIKey=XHOLNRLADUSQLD-UHFFFAOYSA-N

Data  3 KI  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50249298   

TargetProthrombin(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50249298(N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbami...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of human thrombin using acromogenic substrate S-2238 preincubated for 30 mins before substrate addition measured after 20 mins by spectrop...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249298(N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbami...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of Factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249298(N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbami...)
Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells by patch-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProthrombin(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50249298(N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbami...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249298(N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbami...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of tissue plasminogen activatorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249298(N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbami...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of activated anticoagulant protein CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPlasminogen(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249298(N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbami...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of plasminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249298(N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbami...)
Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetProthrombin(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50249298(N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbami...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of human thrombin using substrate S-2238 preincubated for 30 mins followed by substrate addition measured after 20 mins by micro plate rea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2019
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249298(N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbami...)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human factor 10a using substrate S-2765 preincubated for 30 mins followed by substrate addition measured after 20 mins by micro plate r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2019
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249298(N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbami...)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human factor Xa using S-2222 as substrate preincubated for 30 mins followed by substrate addition and measured for 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProthrombin(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50249298(N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbami...)
Affinity DataIC50: 18nMAssay Description:Inhibition of human recombinant thrombin expressed in HEK293 cells using S-2238 as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249298(N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbami...)
Affinity DataKi:  0.117nMAssay Description:Inhibition of Factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249298(N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbami...)
Affinity DataKi:  0.120nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249298(N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbami...)
Affinity DataKi:  1.80E+3nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed