BDBM99917 4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)phenylcarbamothioyl)benzamide::US8501991, Tenovin 6

SMILES CC(C)(C)c1ccc(cc1)C(=O)NC(=S)Nc2ccc(cc2)NC(=O)CCCCN(C)C

InChI Key InChIKey=BVJSXSQRIUSRCO-UHFFFAOYSA-N

Data  16 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 99917   

TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University Court of The University of Dundee

US Patent
LigandPNGBDBM99917(4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)ph...)
Affinity DataIC50: 2.10E+4nMAssay Description:SIRT1 inhibition assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2013
Entry Details
Go to US Patent

TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University Court of The University of Dundee

US Patent
LigandPNGBDBM99917(4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)ph...)
Affinity DataIC50: 5.81E+4nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged SIRT1 (193 to 741 amino acid) after 45 mins by spectrophotometry relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM99917(4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)ph...)
Affinity DataIC50: 2.97E+4nMAssay Description:Inhibition of human recombinant C-terminal His-tagged SIRT2 (13 to 319 amino acid) after 45 mins by spectrophotometry relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University Court of The University of Dundee

US Patent
LigandPNGBDBM99917(4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)ph...)
Affinity DataIC50: 3.75E+4nMAssay Description:Inhibition of recombinant human SitT1 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM99917(4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)ph...)
Affinity DataIC50: 1.04E+4nMAssay Description:Inhibition of recombinant human SitT2 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University Court of The University of Dundee

US Patent
LigandPNGBDBM99917(4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)ph...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human SIRT1 assessed as deacetylation activity using acetylated lysine as substrate measured after 1 hr in presence of NAD+ by by Fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2018
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM99917(4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)ph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human SIRT2 assessed as deacetylation activity using acetylated lysine as substrate measured after 1 hr in presence of NAD+ by by Fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2018
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University Court of The University of Dundee

US Patent
LigandPNGBDBM99917(4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)ph...)
Affinity DataIC50: 2.97E+4nMAssay Description:Inhibition of recombinant human GST or His6-tagged SIRT1 using H2N-HK-[Nepsilon-acetyl-lysine]-LM-COOH as substrate incubated for 10 mins in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2018
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM99917(4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)ph...)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of recombinant human His6-tagged SIRT2 using H2N-HK-[Nepsilon-acetyl-lysine]-LM-COOH as substrate incubated for 12 mins in presence of bet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2018
Entry Details Article
PubMed
LigandPNGBDBM99917(4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)ph...)
Affinity DataIC50: 2.57E+4nMAssay Description:Inhibition of recombinant human His6-tagged SIRT3 using H2N-HK-[Nepsilon-acetyl-lysine]-LM-COOH as substrate incubated for 10 mins in presence of bet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2018
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University Court of The University of Dundee

US Patent
LigandPNGBDBM99917(4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)ph...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human full length SIRT1 expressed in DE3 cells by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase HST2(Baker's yeast)
Institute

Curated by ChEMBL
LigandPNGBDBM99917(4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)ph...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of yeast Hst2 by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University Court of The University of Dundee

US Patent
LigandPNGBDBM99917(4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)ph...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of sirtuin 1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM99917(4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)ph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of sirtuin 2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
LigandPNGBDBM99917(4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)ph...)
Affinity DataIC50: 6.70E+4nMAssay Description:Inhibition of sirtuin 3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM99917(4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)ph...)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of recombinant human SIRT2 using KTcr-I as substrate preincubated for 30 mins followed by substrate addition and measured after 3 hrs in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed