BDBM98027 US10472367, Compound Formula I::US10919901, Compound Formula I::US8487096, I::US9221824, Formula I

SMILES C[C@@H](O)CNC(=O)c1ccc(cc1F)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1

InChI Key InChIKey=HGSJGRWHTKSAOI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 98027   

TargetHepatocyte growth factor receptor(Human)
Incyte

US Patent
LigandPNGBDBM98027(US8487096, I | US9221824, Formula I | US10472367, ...)
Affinity DataIC50: 0.550nMpH: 7.5 T: 2°CAssay Description:Briefly, histidine-tagged c-Met catalytic domain fusion protein (Invitrogen, # PV3143) was used for the assay. IC50 measurements were based on the de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
Go to US Patent

TargetHepatocyte growth factor receptor(Human)
Incyte

US Patent
LigandPNGBDBM98027(US8487096, I | US9221824, Formula I | US10472367, ...)
Affinity DataIC50: 0.550nMpH: 7.5 T: 2°CAssay Description:The compounds of the invention were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values for the inhibition of c-Met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2016
Entry Details
Go to US Patent

TargetHepatocyte growth factor receptor(Human)
Incyte

US Patent
LigandPNGBDBM98027(US8487096, I | US9221824, Formula I | US10472367, ...)
Affinity DataIC50: 0.550nMAssay Description:The compounds of the invention were screened in vitro for their ability to inhibit c-Met kinase activity. Briefly, histidine-tagged c-Met catalytic d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2020
Entry Details
Go to US Patent

TargetHepatocyte growth factor receptor(Human)
Incyte

US Patent
LigandPNGBDBM98027(US8487096, I | US9221824, Formula I | US10472367, ...)
Affinity DataIC50: 0.550nMAssay Description:The compounds of the invention were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values for the inhibition of c-Met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
Go to US Patent