BDBM97713 US8476271, 19::US8846929, 222

SMILES OC(=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3C23CCCC(CCC2)C3)c1=O

InChI Key InChIKey=HQRWWKRMPLZJMJ-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 97713   

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97713(US8846929, 222 | US8476271, 19)
Affinity DataKi:  30.2nMpH: 7.4Assay Description:Radioligand binding assays (screening and dose-displacement) used 0.1nM [3H]-nociceptin (NEN; 87.7 Cl/nimole) with 10-20 ug membrane protein in a fin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
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TargetNociceptin receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97713(US8846929, 222 | US8476271, 19)
Affinity DataKi:  178nM ΔG°:  -9.20kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 μg membrane protein in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
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TargetMu-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97713(US8846929, 222 | US8476271, 19)
Affinity DataKi:  1.86E+3nMpH: 7.4Assay Description:Radioligand dose-displacement binding assays for u-opioid receptors used 0.2nM[3H]-diprenorphine (NEN, Boston, Mass.), with 5-20mg membrane protein/w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
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TargetDelta-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97713(US8846929, 222 | US8476271, 19)
Affinity DataKi:  2.03E+3nMpH: 7.4Assay Description:Radioligand dose-displacement assays used 0.2nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20ug membrane protein (recombinant delta opioid recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
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TargetKappa-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97713(US8846929, 222 | US8476271, 19)
Affinity DataKi:  2.89E+3nMpH: 7.4Assay Description:Radioligand dose displacement assays used 0.4-0.8nM [3H]-U69,593 (NEN; 40 Ci/mmole) with 10-20 ug membrane protein (recombinant kappa opioid receptor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
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TargetMu-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97713(US8846929, 222 | US8476271, 19)
Affinity DataKi:  4.03E+3nM ΔG°:  -7.35kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand dose displacement assays used 0.4-0.8 nM [3H]-U69,593 (NEN; 40 Ci/mmole) with 10-20 μg membrane protein (recombinant kappa opioid rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
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TargetKappa-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97713(US8846929, 222 | US8476271, 19)
Affinity DataKi:  5.35E+3nM ΔG°:  -7.19kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand dose-displacement binding assays for μ-opioid receptors used 0.2 nM[3H]-diprenorphine (NEN, Boston, Mass.), with 5-20 mg membrane prot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
Go to US Patent

TargetKappa-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97713(US8846929, 222 | US8476271, 19)
Affinity DataKi: >2.00E+4nM ΔG°: >-6.41kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand dose-displacement binding assays for μ-opioid receptors used 0.2 nM[3H]-diprenorphine (NEN, Boston, Mass.), with 5-20 mg membrane prot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
Go to US Patent