BDBM97710 US8476271, 16::US9145408, 362
SMILES OC(=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3C2CC3CCCC(C3)C2)c1=O
InChI Key
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 97710
Affinity DataEC50: 4.03nMpH: 7.4 T: 2°CAssay Description:Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like (ORL-1) (Receptor Biology) were prepared by lysing cells in ice-co...More data for this Ligand-Target Pair
Affinity DataEC50: >2.00E+4nMpH: 7.4 T: 2°CAssay Description:[35S]GTP gamma S functional assays were conducted using freshly thawed mu-receptor membranes. Assay reactions were prepared by sequentially adding th...More data for this Ligand-Target Pair
Affinity DataEC50: >2.00E+4nMpH: 7.4 T: 2°CAssay Description:Functional [35S]GTPgammaS binding assays were conducted as follows. Kappa opioid receptor membrane solution was prepared by sequentially adding final...More data for this Ligand-Target Pair
Affinity DataKi: 2.40nM ΔG°: -11.8kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 μg membrane protein in a ...More data for this Ligand-Target Pair
Affinity DataKi: 2.40nM ΔG°: -10.9kcal/molepH: 7.4 T: 2°CAssay Description:Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Receptor Biology) were prepared by lysing cells ...More data for this Ligand-Target Pair
Affinity DataKi: 1.63E+3nM ΔG°: -7.89kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand dose displacement assays used 0.4-0.8 nM [3H]-U69,593 (NEN; 40 Ci/mmole) with 10-20 μg membrane protein (recombinant kappa opioid rece...More data for this Ligand-Target Pair
Affinity DataKi: 1.63E+3nM ΔG°: -7.89kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand dose-displacement binding assays for mu-opioid receptors used 0.2 nM[3H]-diprenorphine (NEN, Boston, Mass.), with 5-20 mg membrane protei...More data for this Ligand-Target Pair
Affinity DataKi: 2.28E+3nM ΔG°: -7.69kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand dose-displacement binding assays for μ-opioid receptors used 0.2 nM[3H]-diprenorphine (NEN, Boston, Mass.), with 5-20 mg membrane prot...More data for this Ligand-Target Pair
Affinity DataKi: 2.28E+3nM ΔG°: -7.15kcal/molepH: 7.4 T: 2°CAssay Description:Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned in house) were prepared by lysing cells in ice co...More data for this Ligand-Target Pair
Affinity DataKi: 4.76E+3nM ΔG°: -7.26kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand dose-displacement binding assays for μ-opioid receptors used 0.2 nM[3H]-diprenorphine (NEN, Boston, Mass.), with 5-20 mg membrane prot...More data for this Ligand-Target Pair
Affinity DataKi: 4.76E+3nM ΔG°: -7.26kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 ug membrane protein (recombinant delta opioid recep...More data for this Ligand-Target Pair