BDBM9483 3-(1H-Imidazol-1-ylmethyl)-7-methoxy-4-phenyl-2H-chromen-2-one::CHEMBL224787::Coumarin deriv. 32

SMILES COc1ccc2c(-c3ccccc3)c(Cn3ccnc3)c(=O)oc2c1

InChI Key InChIKey=KNUCUIJPALCQFL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 9483   

TargetAromatase(Human)
University of Bari

LigandPNGBDBM9483(CHEMBL224787 | 3-(1H-Imidazol-1-ylmethyl)-7-methox...)
Affinity DataIC50: 106nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta, 2beta-3H] testosterone or [1beta-3H] androstenedione during aroma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2006
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
University of Bari

LigandPNGBDBM9483(CHEMBL224787 | 3-(1H-Imidazol-1-ylmethyl)-7-methox...)
Affinity DataAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta, 2beta-3H] testosterone or [1beta-3H] androstenedione during aroma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2006
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bari

LigandPNGBDBM9483(CHEMBL224787 | 3-(1H-Imidazol-1-ylmethyl)-7-methox...)
Affinity DataIC50: 106nMAssay Description:Inhibition of human aromatase-mediated conversion of [1beta3H]androstenedione to estrone by liquid scintillation counting in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed