BDBM92674 Isoquinolinesulfonamide, CKI-7

SMILES c1cc(c2ccncc2c1S(=O)(=O)NCCN)Cl

InChI Key InChIKey=OGKYMFFYOWUTKV-UHFFFAOYSA-N

Data  7 IC50

PDB links: 4 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 92674   

TargetCasein kinase I isoform alpha(Human)
Nagoya University School of Medicine

LigandPNGBDBM92674(Isoquinolinesulfonamide, CKI-7)
Affinity DataIC50: 9.50E+3nMpH: 7.4 T: 2°CAssay Description:Casein kinase activities were determined under the conditions as described by Huang et al (1982).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2013
Entry Details
PubMed
TargetCasein kinase II subunit alpha(Human)
Nagoya University School of Medicine

LigandPNGBDBM92674(Isoquinolinesulfonamide, CKI-7)
Affinity DataIC50: 9.00E+4nMpH: 7.4 T: 2°CAssay Description:Casein kinase activities were determined under the conditions as described by Huang et al (1982).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2013
Entry Details
PubMed
TargetProtein kinase C alpha type(Human)
Nagoya University School of Medicine

LigandPNGBDBM92674(Isoquinolinesulfonamide, CKI-7)
Affinity DataIC50: 1.00E+6nMpH: 7.4 T: 2°CAssay Description:Casein kinase activities were determined under the conditions as described by Huang et al (1982).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2013
Entry Details
PubMed
TargetcAMP-dependent protein kinase type I-alpha regulatory subunit(Bovine)
Nagoya University School of Medicine

LigandPNGBDBM92674(Isoquinolinesulfonamide, CKI-7)
Affinity DataIC50: 5.50E+5nMpH: 7.4 T: 2°CAssay Description:Casein kinase activities were determined under the conditions as described by Huang et al (1982).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2013
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase II inhibitor 2(Bovine)
Nagoya University School of Medicine

LigandPNGBDBM92674(Isoquinolinesulfonamide, CKI-7)
Affinity DataIC50: 1.95E+5nMpH: 7.4 T: 2°CAssay Description:Casein kinase activities were determined under the conditions as described by Huang et al (1982).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2013
Entry Details
PubMed
TargetCasein kinase I isoform alpha(Human)
Nagoya University School of Medicine

LigandPNGBDBM92674(Isoquinolinesulfonamide, CKI-7)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CK1 using KRRRALS(p)VASLPGL as substrate after 40 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetCasein kinase I isoform alpha/delta/epsilon/gamma-1/gamma-2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM92674(Isoquinolinesulfonamide, CKI-7)
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of CK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed